微波消融的净功率及净能量的离体、活体猪肝对比实验观察  

Net power and energy of cooled antenna microwave ablation： ex vivo versus in vivo results in porcine liver

作　　者：姜华[1] 范卫君[1] 张亮[1] 李新[1] 张建磊[1] 

机构地区：[1]华南肿瘤学国家重点实验室中山大学附属肿瘤医院影像介入中心,广州 510060

出　　处：《中华医学杂志》2012年第35期2513-2517,共5页National Medical Journal of China

基　　金：基金项目：广东省科技计划项目（2011B080701032）

摘　　要：目的观察离体、活体猪肝微波消融过程中实际到达微波天线辐射器的净功率及净能量，并初步探讨净能量与消融体积之间的关系。方法根据微波消融的工作原理，遵循能量守恒定律设计实验，以30副离体猪肝、5副活体猪肝为研究对象，分别行50w×10min、80w×10min、110WX10min微波消融，每个组合重复5次，通过测定微波天线输入端功率，计算微波天线损耗的能量，研究微波消融的净功率、净能量，以及净功率和主机输出功率之间的变化关系，初步探讨净能量与消融体积的关系。结果当主机输出功率为50、80、110W时，离体、活体猪肝微波消融的净功率分别为（31．3±0．6）W、（47．3±0．8）W、（62．1±0．9）W和（31．8±0．8）W、（47．4±0．3）w、（61．7±1．5）W，且主机输出功率相同时，离体、活体的净功率差异无统计学意义（P=0．841，0．133，0．551）。主机输出功率为50、80、110W时，离体微波天线耗损的能量与微波天线输入端能量的比值恒定（P：0．613，0．326）。净功率相同时，离体、活体消融体积差异有统计学意义（P=0．001，0．006，0．001）。结论以净功率代替传统主机输出功率作为微波消融的参考标准更加精确，净能量更真实的反映了微波对组织的消融能量。Objective To explore the net power and net energy of a cooled antenna radiator in ex vivo and in vivo porcine livers. Methods All animal experiments complied with the guidelines of our animal use committee. Microwave ablation （MWA） was performed in ex vivo and in vivo porcine livers with a cooled- shaft antenna in different microwave ablation parameter groups （50, 80 and 110 W for 10 min）. The energy losses from the microwave antenna or cables were calculated. And the net power, net energy and the relationship between net power and power readout were determined. Results When the power displayed by the machine indicated 50 W, 80 W and 110 W, the net power during MWA was 31.3±0. 6, 47.3 ±0. 8 and 62. 1 ±0. 9 W ex vivo and 31.8± 0. 8, 47.4 ±0. 3 and 61.7 ± 1.5 W in vivo. For the same power readout, the ex vivo or in vivo effective power was the same （P =0. 841, P =0. 133, P =0. 551 ）. For both ex vivo and in vivo experiments, the ratio of microwave antenna energy loss to microwave antenna input energy was relatively constant （P = 0. 613, 0. 326）. For the same treatment time and net power, the difference was significant between ex vivo and in vivo ablation volumes （P =0. 001, 0. 006, 0. 001）. Conclusion Using net power as a reference during MWA is more accurate compared to the traditional power readout. And net energy offers a more realistic reflection of MWA energy in tissues.

关 键 词：微波 消融技术 肝 

分 类 号：R735.7[医药卫生—肿瘤]