肿瘤坏死因子相关凋亡诱导配体受体、死亡受体5及诱骗受体2在子宫内膜癌中的表达及其临床意义  

Expression and clinical significance of the deathreceptor 5 and decoyreceptor 2 of TNF-related apoptosis-inducing ligand in endometrial cancer

作　　者：梁利梅[1] 王才智[1] 刘淑玉[1] 

机构地区：[1]蚌埠医学院第一附属医院妇产科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2012年第10期1162-1165,共4页Journal of Bengbu Medical College

摘　　要：目的:检测人肿瘤坏死因子相关凋亡诱导配体(TNF-related apoptosis-inducing ligand,TRAIL)的诱骗受体2(DcR2)、死亡受体5(DR5)在子宫内膜癌的表达及其临床意义。方法:采用免疫组织化学SP法检测52例子宫内膜癌组织、20例不典型增生子宫内膜组织、23例正常子宫内膜组织中DR5、DcR2阳性表达水平。并对子宫内膜癌患者的手术病理分析、肿瘤分化程度、组织类型、肌层浸润等临床病理因素进行分析。结果:DcR2在正常子宫内膜组织中的表达高于子宫内膜癌组织(P<0.01);DR5在正常子宫内膜、不典型增生子宫内膜和子宫内膜癌组织中的表达呈递增趋势,两两比较差异均有统计学意义(P<0.01)。结论:子宫内膜癌细胞由于高表达DR5和低表达DcR2而易被TRAIL诱导凋亡,这一结果为临床治疗子宫内膜癌提供可能实验依据。Objective： To investgate the expression and clinical significance of the deathreceptor 5 （ DR 5 ） and decoyreceptor 2 （ DcR2） of TNF-related apoptosis-inducing ligand （TRAIL） in endometrial cancer. Methods： The expressions of DR5 and DcR2 of endometrium tissues from 52 cases with endometrial cancer, 20 cases with atypical endometrium hyperplasia and 23 cases normal endometrium tissue were detected by immunohistochemistry. The pathological grade of surgery, tumor differentiation degree, tissue type, muscular layer infiltration and clinical pathological factors of endometrial cancer were analyzed. Results：The expressions of DcR2 of normal endometrium tissue were higher than that of endometrial cancer tissue （ P 〈 0.01 ）. The expressions of DR5 of normal endometrium, atypical endometrium hyperplasia and endometrial cancer tissue showed increasing trend, the results of multiple comparison had statistically significant （ P 〈 0.01 ）. Conclusions ： Endometrium carcinoma cells can be easily induced apoptosis by TRAIL with high expression of DR5 and low expression of DcR2 ,which can provide a basis for treating endometrium carcinoma.

关 键 词：子宫肿瘤 肿瘤坏死因子相关诱导配体 诱骗受体2 死亡受体5 细胞凋亡 免疫组织化学 

分 类 号：R787.33[医药卫生—口腔医学]