Association of fucosyltransferase 2 gene variants with ulcerative colitis in Han and Uyghur patients in China  

作　　者：Ayinuer Aheman He-Sheng Luo Feng Gao 

机构地区：[1]Department of Gastroenter- ology, Renmin Hospital of Wuhan University, Wuhan University Medical School, Wuhan 430060, Hubei Province, China [2]Department of Gastroenterology, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi 830001, Xinjiang Uyghur Autonomous Region, China

出　　处：《World Journal of Gastroenterology》2012年第34期4758-4764,共7页世界胃肠病学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China,No. 30871148 and No. 81160052;Natural Science Foundation of Xinjiang Uyghur Autonomous Region of China, No.2009211A26

摘　　要：AIM:To investigate the contribution of fucosyltransferase 2 (FUT2) variants to the genetic susceptibility and clinical heterogeneity of ulcerative colitis (UC) between Han and Uyghur patients in Xinjiang, China. METHODS:A total of 102 UC patients (53 Han patients including 22 men and 31 women, and 49 Uyghur patients including 25 men and 24 women; aged 48 ± 16 years) and 310 age-and sex-matched healthy controls were enrolled from January 2010 to May 2011 in Xinjiang People's Hospital of China. UC was diagnosed based on the clinical, endoscopic and histological findings following Lennard-Jones criteria. Blood samples were collected and genomic DNA was extracted by the routine laboratory methods. Polymerase chain reaction-sequence-based typing method was used to identify FUT2 variants rs281377, rs1047781, rs601338 and rs602662. Genotypic and allelic frequencies were documented and compared between the UC patients and the healthy controls. Genotypic frequencies were also compared between Han and Uyghur patients. Potential association of genetic variation and UC between Han and Uyghur patients was examined. RESULTS: rs281377 was found significantly associated with UC in the Han population as compared with the controls (P = 0.011) while rs281377 was not associated with UC in the Uyghur population (P = 0.06). TT homozygous rs281377 frequencies were higher in the UC groups than in the controls (88.7% vs 68.7% and 55.1% vs 50.3%). rs1047781 was specifically associated with UC in the Uyghur population (P = 0.001), but not associated with UC in the Han population (P = 0.13). TT homozygous rs1047781 frequencies were lower in the UC groups than in the controls (9.5% vs 11.8% and 4.0% vs 6.7%). rs601338 was statistically related to UC in both populations (Han, P = 0.025; Uyghur, P = 8.33 × 10 -5 ). AA homozygous rs601338 frequencies were lower in the UC groups than in the controls (0% vs 1.8% and 12.2% vs 13.4%). No association was found between rs602662 and UC in both Han and the Uyghur populations. Allelic analysis showed AIM：To investigate the contribution of fucosyltransferase 2 （FUT2） variants to the genetic susceptibility and clinical heterogeneity of ulcerative colitis （UC） between Han and Uyghur patients in Xinjiang, China. METHODS：A total of 102 UC patients （53 Han pa- tients including 22 men and 31 women, and 49 Uyghur patients including 25 men and 24 women; aged 48 ± 16 years） and 310 age-and sex-matched healthy controls were enrolled from January 2010 to May 2011 in Xinjiang People’s Hospital of China. UC was diagnosed based on the clinical, endoscopic and histological findings following Lennard-Jones criteria. Blood samples were collected and genomic DNA was extracted by the routine laboratory methods. Polymerase chain reaction-sequence-based typing method was used to identify FUT2 variants rs281377, rs1047781, rs601338 and rs602662. Genotypic and allelic frequencies were documented and compared between the UC patients and the healthy controls. Genotypic frequencies were also compared between Han and Uyghur patients. Potential association of genetic variation and UC between Han and Uyghur patients was examined. RESULTS： rs281377 was found significantly associated with UC in the Han population as compared with the controls （P = 0.011） while rs281377 was not associated with UC in the Uyghur population （P = 0.06）. TT homozygous rs281377 frequencies were higher in the UC groups than in the controls （88.7% vs 68.7% and 55.1% vs 50.3%）. rs1047781 was specifically associated with UC in the Uyghur population （P = 0.001）, but not associated with UC in the Han population （P = 0.13）. TT homozygous rs1047781 frequencies were lower in the UC groups than in the controls （9.5% vs 11.8% and 4.0% vs 6.7%）. rs601338 was statistically related to UC in both populations （Han, P = 0.025; Uyghur, P = 8.33 × 10 -5 ）. AA homozygous rs601338 frequencies were lower in the UC groups than in the controls （0% vs 1.8% and 12.2% vs 13.4%）. No association was found between rs602662 and UC in both Ha

关 键 词：Ulcerative colitis Fucosyltransferase 2 Genepolymorphisms HAN UYGHUR 

分 类 号：R574.62[医药卫生—消化系统]