p33ING1b在胶质瘤中的表达及意义  

Expression and significance of p33ING1b in brain glioma

作　　者：潘模英[1] 方志敏[2] 康元宝[2] 林志萍[1] 

机构地区：[1]福建莆田学院医学院基础医学部,福建莆田351100 [2]福建莆田学院附属医院神经外科,福建莆田351100

出　　处：《黑龙江医药科学》2012年第4期31-32,共2页Heilongjiang Medicine and Pharmacy

基　　金：福建省教育厅A类面上项目;编号:JA08187

摘　　要：目的:检测抑癌基因p33ING1b在脑胶质瘤中的表达及其意义。方法:选取行脑胶质瘤手术切除的新鲜胶质瘤组织标本66例及正常脑组织15例,应用S-P免疫组织化学方法检测p33ING1b在瘤组织及正常组织中的表达。结果:p33ING1b在66例胶质瘤标本中的阳性表达率为71.2%(47/66),而在正常组织中全部为阳性表达(100%);且随着肿瘤级别的增高,p33ING1b的表达水平呈明显的下降趋势。结论:p33ING1b在胶质瘤组织中低表达,且与肿瘤恶性程度密切相关,检测其表达水平将为判断肿瘤的恶性程度、确定治疗策略及评估预后提供一定的帮助。Objective.To explore the expression of p33INGlb in brain gliomas and its clinical significance. Methods： Immunohistochemical staining was used to examine the expression of p33INGlb in 66 fresh samples of gliomas and 15 control tissues. The SPSS 16. 0 was used for statistical analysis. Results： The difference in p33INGlb expression was significant in every grade and their expression levels were decreased with increasing grade progress of gliomas. Conclusion：There was a low expression of p33INGlb in gliomas. The expression of p33INGlb is related to the malignancy of the gliomas.

关 键 词：胶质瘤 P33ING1B 

分 类 号：R730.264[医药卫生—肿瘤] Q786[医药卫生—临床医学]