壳聚糖希夫碱金属[Cu(Ⅱ),Mn(Ⅱ)]配合物的合成及其抑菌活性  

Synthesis and Antibacterial Activities of Chitosan Schiff-base Metal[Cu(Ⅱ),Mn(Ⅱ)] Complexes

作　　者：刘正华 乐学义[2] 陈实[2] 周晓华[2] 范玲[2] 

机构地区：[1]中山市小榄农产品质量检验检测中心,广东中山528415 [2]华南农业大学理学院生物材料研究所,广东广州510642

出　　处：《合成化学》2012年第5期599-602,608,共5页Chinese Journal of Synthetic Chemistry

基　　金：广东省科技计划项目(2010B020311010);华南农业大学"211工程"三期重点建设项目(2009B010100001)

摘　　要：壳聚糖的氨基与水杨醛发生反应制得壳聚糖希夫碱配体(L);L与铜盐或锰盐发生配位反应制得壳聚糖希夫碱金属[Cu(Ⅱ)和Mn(Ⅱ)]配合物(1和2),其结构经UV,IR,TGA和荧光光谱表征。L的酚亚胺的N原子和酚羟基的O原子同时参与配位。抑菌活性测试结果表明,1和2对大肠杆菌,金黄色葡萄球菌,沙门氏菌和枯草杆菌的抑菌活性较配体和金属盐均有明显提高。Chitosan Schiff-base（L） was synthesized by the reaction of chitosan with salicylaldehyde.Chitosan Schiff-base metal[Cu（Ⅱ） and Mn（Ⅱ）] complexes（1 and 2） were prepared by the reaction of L with Cu（Ⅱ） salt and Mn（Ⅱ） salt,respectively.The structures were characterized by UV,IR,TGA and fluoresecence spectroscopy.The results showed that N atom of C=N and O atom of O-H in L involved in coordination with metal ions simultaneously.The priliminary fungicidal activities tests showed that 1 and 2 exhibited good antibacterial activities against Escherichia coli,Staphylococcus aureus,Salmonella enteriditis and Bacillus subtilis compared with L and metal salts.

关 键 词：壳聚糖 希夫碱 Cu(Ⅱ) Mn(Ⅱ) 配合物 合成 抑菌活性 

分 类 号：O627.12[理学—有机化学] O636.1[理学—化学]