普伐他汀联合髓芯减压术治疗激素性兔股骨头坏死对VEGFmRNA表达水平的影响  

作　　者：乐锦波[1] 杜远立[1] 向选平[1] 茹能[1] 

机构地区：[1]三峡大学人民医院(宜昌市第一人民医院),443000

出　　处：《浙江临床医学》2012年第9期1028-1029,1032,共3页Zhejiang Clinical Medical Journal

摘　　要：目的研究普伐他汀联合髓芯减压术治疗激素性兔股骨头坏死对组织病理学和血管内皮生长因子（VEGF）mRNA表达水平的影响。方法45只实验大白兔制作成激素性股骨头坏死模型后随机分为3组：髓芯减压术治疗组（A组），普伐他汀联合髓芯减压术治疗组（B组）和模型组（C组），每组各15只。观察各组各时期兔股骨头毛细血管数、管径、骨陷窝空缺百分比以及VEGFmRNA表达水平。结果A、B两组等4周VEGFmRNA表达水平与C组比较，差异无统计学意义（P〉O．05），而B组第8周和第12周VEGFmRNA表达水平明显高于A、C组（V〈0．05），且随治疗时间延长，B组VEGFmRNA表达水平明显升高（P〈0．05）。结论普伐他汀联合髓芯减压术可明显上调股骨头VEGFmRNA的表达水平，是治疗激素性股骨头坏死的有效方法。Objective To observe the expression levels of VEGF mRNA and histopathology of core decompression on treatment of corticosteroid-induced femoral head osteonecrosis in rabbits. Methods 45 experimental rabbits were made to the model of steroid-induced osteonecrosis and were randomly divided into 3 groups： Core decompression treatment group （ A group ） , pravastatin combined with core decompression treatment group （ B group ） and the model group （ C group ） , every group was 15 rabbits. The capillary number, diameter, percentage of vacant lacunae and VEGF mRNA in the femoral head at different periods were observed. Results The expression of VEGF mRNA in A, B groups at 4 weeks showed no significant difference with C groups （P〉0.05） , while the expression ofVEGF mRNA in B group at 8 weeks and 12 weeks were significantly higher than that of A, C group （ P〈0.05 ） , and with prolonged treatment, the expression of VEGF mRNA in B group was significantly higher （ P〈0.05 ） .Conclusion The treatment ofpravastatin combined with core decompression can significantly increased the expression levels ofVEGF mRNA in femoral head. It was an effective method to treat the femoral head necrosis.

关 键 词：普伐他汀 髓芯减压术 激素性股骨头坏死 血管内皮生长因子 

分 类 号：R737.31[医药卫生—肿瘤]