甘露聚糖肽与高聚生治疗恶性胸腔积液的疗效比较  

Comparison of Mannatide and Highly Agglutinative Staphylococcin in treatment of Malignant Pleural Effusion

作　　者：陆国军[1] 于力克[1] 张宇[1] 

机构地区：[1]南京市胸科医院呼吸科,江苏南京210029

出　　处：《临床肺科杂志》2012年第10期1846-1847,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的研究甘露聚糖肽与高聚生治疗恶性胸腔积液的疗效。方法 50例恶性胸腔积液患者随机分为两组,分别向胸腔内注入甘露聚糖肽、高聚生治疗,观察两组毒副反应,评价比较二者的有效率。结果两组毒副反应轻微,主要为消化道反应;甘露聚糖肽组治疗有效率52%,高聚生组治疗有效率为80%,两组比较差异有统计学意义。结论胸腔内注入甘露聚糖肽与高聚金葡素对恶性胸腔积液的治疗安全、有效,高聚金葡素的疗效高于甘露聚糖肽。Objective To study and compare the effectiveness of mannatide and highly agglutinative staphylococcin （HAS） in treating malignant pleural effusion. Methods 50 patients with malignant pleural effusion were randomly divided into mannatide group and HAS group. After complete drainage of pleura[ fluid, the 50 patients were allocated to receive mannatide or HAS by intrapleural injection. The clinical efficacy and adverse reactions were observed and compared according to WHO standard. Results The two groups had little adverse reactions with gastrointestinal reaction. The effective rate of mannatide group was 52%, 80% in HAS group, and there was signif- icant difference between two ~oups （ P 〈 0. 05 ）. Conclusion Treatment of mannatide or HAS by intrapleural injection in malignant pleura] effusion is safe and effective. Intrapleural HAS injection in the treatment of malignant pleura[ effusion is seemed to be better than intrapleural mannatide injection.

关 键 词：甘露聚糖肽 高聚金葡素 恶性胸腔积液 

分 类 号：R730.5[医药卫生—肿瘤]