GPP方案治疗老年人复发难治性NHL 34例疗效观察  

Effect of Gemcitabine Plus Oxaliplatin and Prednisone(GPP) in Treatment of Elderly 34 Patients with Relapsed or Refractory Non-Hodgkin's Lymphoma

作　　者：陈慧华 杨兰平 文玲波 

机构地区：[1]柳州市肿瘤医院化疗科,545006

出　　处：《实用癌症杂志》2012年第5期503-505,共3页The Practical Journal of Cancer

摘　　要：目的探讨吉西他滨联合奥沙利铂、强的松治疗老年复发难治性淋巴瘤的疗效及安全性。方法 34例经病理及免疫组化诊断证实的Ⅲ～Ⅳ期老年复发难治NHL。GEM 800～1 000 mg/m2+生理盐水100 ml静脉滴注60 min,第1,8天;L-OHP 75 mg/m2+5%葡萄糖注射液250 ml静脉滴注3～4 h,第1天;强的松20～40 mg/m2,口服,第1～5天。21～28天为1个周期,完成2个周期以上者做疗效评价。结果 34例患者中完全缓解(CR)9例,部分缓解(PR)16例,稳定(SD)4例,进展(PD)5例,总有效率73.5%。骨髓抑制Ⅲ～Ⅳ度10例,发生率29.4%,未发生治疗相关性死亡。结论吉西他滨联合奥沙利铂、强的松治疗老年复发难治性NHL效果肯定,属于高效低毒的挽救性方案。Objective To explore efficacy and safety of gemcitabine combined with Oxaliplatin and Prednisone（GPP） in the treatment of patients with elderly relapsed and refractory NHL.Methods 34 cases pathologically and immunohistochemically confirmed,stage Ⅲ～ Ⅳ elderly relapsed and refractory NHL were treated with GEM 800～1 000 mg/m2 in 60 minutes on d1,8;L-OHP 75 mg/m2 in d1;and PDN 40 mg/m2,p.o,on d1～ 5.The chemotherapy was repeated every 21～28 days.Treatment results were evaluated after two cycles of chemotherapy.Results Of 34 assessable patients,the complete response（CR） and the partial response（PR） were seen in 9 and 16 cases,respectively.4 patients had stable disease and 5 patients had progressed disease.The overall response rate（CR＋ PR） was 73.5%.Grade Ⅲ ～ Ⅳ bone marrow suppression was seen in 10 cases,with an incidence rate of 29.4%.There was no treatment-related death.Conclusion Gemcitabine plus oxaliplatin and prednisolone are effective in the treatment of elderly patients with relapsed or refractory NHL

关 键 词：吉西他滨 奥沙利铂 强的松 老年人 复发难治性非霍杰金氏淋巴瘤 

分 类 号：R733.1[医药卫生—肿瘤]