A post-classical theory of enamel biomineralization… and why we need one  

作　　者：James P Simmer Amelia S Richardson Yuan-Yuan Hu Charles E Smith Jan Ching-Chun Hu 

机构地区：[1]Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, USA [2]Facility for Electron Microscopy Research, Department of Anatomy and CellBiology and Faculty ofDent,stry, ,McG,lI,University. Montreal, Canada

出　　处：《International Journal of Oral Science》2012年第3期129-134,共6页国际口腔科学杂志（英文版）

基　　金：supported by NIDCR/NIH grant projects DE011301 and DE061854

摘　　要：Enamel crystals are unique in shape, orientation and organization. They are hundreds of thousands times longer than they are wide, run parallel to each other, are oriented with respect to the ameloblast membrane at the mineralization front and are organized into rod or interrod enamel. The classical theory of amelogenesis postulates that extracellular matrix proteins shape crystallites by specifically inhibiting ion deposition on the crystal sides, orient them by binding multiple crystallites and establish higher levels of crystal organization. Elements of the classical theory are supported in principle by in vitro studies; however, the classical theory does not explain how enamel forms in vivo. In this review, we describe how amelogenesis is highly integrated with ameloblast cell activities and how the shape, orientation and organization of enamel mineral ribbons are established by a mineralization front apparatus along the secretory surface of the ameloblast cell membrane.Enamel crystals are unique in shape, orientation and organization. They are hundreds of thousands times longer than they are wide, run parallel to each other, are oriented with respect to the ameloblast membrane at the mineralization front and are organized into rod or interrod enamel. The classical theory of amelogenesis postulates that extracellular matrix proteins shape crystallites by specifically inhibiting ion deposition on the crystal sides, orient them by binding multiple crystallites and establish higher levels of crystal organization. Elements of the classical theory are supported in principle by in vitro studies; however, the classical theory does not explain how enamel forms in vivo. In this review, we describe how amelogenesis is highly integrated with ameloblast cell activities and how the shape, orientation and organization of enamel mineral ribbons are established by a mineralization front apparatus along the secretory surface of the ameloblast cell membrane.

关 键 词：AMELOBLASTIN AMELOGENIN ENAMELIN mineralization front TOOTH 

分 类 号：R783[医药卫生—口腔医学]