1,2,3,4-四氢喹啉类化合物合成与应用的研究进展  

Advances in the synthesis and application of 1,2,3,4-tetrahydroquinoline derivatives

作　　者：郭辉[1] 庄玉伟[1] 王颖[1] 曹健[1] 郭晓战 张国宝[1] 

机构地区：[1]河南省科学院高新技术研究中心,河南郑州450002

出　　处：《化工进展》2012年第10期2288-2294,共7页Chemical Industry and Engineering Progress

摘　　要：1,2,3,4-四氢喹啉类化合物是治疗心血管病药物和染料的中间体。综述了1,2,3,4-四氢喹啉类化合物合成及应用的研究进展,分析比较了氢化反应、Diels-Alder反应、多步反应、多组分反应、多米诺反应等合成方法的优缺点,讨论了1,2,3,4-四氢喹啉类化合物在药物化学和染料合成领域的应用现状,并对其研究前景进行了展望:发展具有原子经济性合成方法及光学纯1,2,3,4-四氢喹啉类化合物的合成及应用。1,2,3,4-tetrahydroquinoline derivatives are important intermediates of cardiovascular drugs and dye.The recent advances in the synthesis and application of 1,2,3,4-tetrahydroquinoline derivatives are reviewed in this paper.Different synthetic methods,including hydrogenation reaction,Diels-Alder reaction,multi-step reaction,multi-component reaction,and domino reaction,are compared,and the applications of 1,2,3,4-tetrahydroquinoline derivatives in medicinal chemistry and dye are also discussed.From the view of synthesis and practical applications,the research perspective of 1,2,3,4-tetrahydroquinoline derivatives is outlined in the end of this paper,which are the development of atom-economic methods and the synthesis and application of enantiomerically pure 1,2,3,4-tetrahydroquinoline derivatives.

关 键 词：1 2 3 4-四氢喹啉类化合物 药物化学 染料 合成 

分 类 号：O626.32[理学—有机化学]