帕洛诺司琼与阿扎司琼治疗铂类药物所致急性呕吐的成本-效果分析  

Cost-effectiveness analysis of two preventing schemes for cisplatinand oxalipatin-induced acute vomiting

作　　者：曾冬香[1] 毕延智[1] 杨全良[1] 马剑[1] 

机构地区：[1]苏州大学附属常州肿瘤医院肿瘤内科,江苏常州213001

出　　处：《实用肿瘤杂志》2012年第5期511-513,共3页Journal of Practical Oncology

基　　金：江苏省常州市卫生创新人才培养工程资助项目

摘　　要：目的比较两种5-HT3受体拮抗剂治疗顺铂及草酸铂所致急性呕吐的经济学效果。方法患者化疗期间分别予以帕洛诺司琼或阿扎司琼止吐,分组如下:A组(应用顺铂/帕洛诺司琼),B组(应用顺铂/阿扎司琼),C组(应用草酸铂/帕洛诺司琼),D组(应用草酸铂/阿扎司琼)。观察对于急性呕吐反应的有效率,并采用药物经济学方法进行成本-效果分析。结果对于顺铂所致急性呕吐,A、B两组的有效率分别为85.0%、80.4%,差异无统计学意义(P>0.05);对于草酸铂所致急性呕吐,C、D两组的有效率分别为91.2%、87.7%,差异无统计学意义(P>0.05),4组成本分别为925.2元、349.5元、896.3元及235.7元。结论对于中、高度致吐药物(草酸铂或顺铂)所致急性呕吐,阿扎司琼仍不失为最佳选择,而帕洛诺司琼可能更适用于经济条件较好的患者。Objective To evaluate the cost-effectiveness of two 5-HT3 receptor suppressant preventing schemes for cisplatin-and oxalipatin-induced vomiting.Methods Patients receiving cisplatin or oxaliplatin chemotherapy were randomly divided into four groups according to the preventing schemes：Group A and Group C（treated with palonosetron）;Group B and Group D（treated with azasetron）.The data were analyzed using pharmacoeconomic cost-effectiveness analysis.Results Response rates of prevention of acute vomiting were 85.0%,80.4% for Group A and Group C;91.2%,87.7% for Group B and Group D（P0.05）.The costs were 925.2,349.5,896.3 and 235.7 yuan for 4 Groups,respectively.Conclusions For the prevention of acute vomiting induced by cisplatin or oxaliplatin,azasetron is more optimal,granisetron may be preferable for patients with good economical condition.

关 键 词：肿瘤/药物疗法 帕洛诺司琼/治疗应用 阿扎司琼/治疗应用 呕吐 费用效益分析 

分 类 号：R730.53[医药卫生—肿瘤] R975.4[医药卫生—临床医学]