子痫前期伴牙周炎患者血清TNF-α、IL-6及CRP水平的检测  

Detection of serum TNF-α、IL-6 and CRP level in patients with preeclampsia and periodontal disease

作　　者：姚丽[1] 孙钦峰[2] 杨春惠[1] 

机构地区：[1]山东中医药大学第二附属医院口腔科,济南250001 [2]山东大学口腔医学院牙周科,济南250012

出　　处：《山东大学学报（医学版）》2012年第10期123-126,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨慢性牙周炎与子痫前期患者血清中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和C-反应蛋白(C-reactive protein,CRP)水平变化及相关关系。方法选取经确诊的26～36周的伴牙周炎的子痫前期妊娠妇女[(PE+CP)组]21例,单纯子痫前期妊娠妇女(PE组)21例,单纯慢性牙周炎妊娠妇女(CP组)21例,无以上2种疾病及其他系统性疾病的正常健康妊娠妇女(H组)21例。记录菌斑指数(PI)、牙周探诊深度(PD)、附着水平丧失(AL)和探诊出血(BOP),检测血清中TNF-α、IL-6及CRP的含量。结果各组间牙周病指数(PD、AL、BOP)比较有统计学差异。(PE+CP)组、PE组、CP组与H组相比,TNF-α、IL-6、CRP水平明显升高,差异有统计学意义(P<0.05),(PE+CP)组的TNF-α、IL-6、CRP水平均高于PE组及CP组,差异有统计学意义(P<0.05)。结论 TNF-α、IL-6、CRP可能与子痫前期和牙周炎病理机制相关,牙周炎和子痫前期之间存在一定的关联。Objective To explore the change and possible relationship of serum levels of tumor necrosis factor-alpha （TNF-α） interleukin-6 （ IL-6 ） C-reactive protein （CRP） in patients with chronic periodontitis （CP） and preeclampsia （PE）. Methods A case-control study was carried out that included 42 preeclamptic and 42 non- preeclamptic pregnant women between 26 to 36 weeks of pregnancy. Among them, 21 were patients with PE and CP （ group PE ＋ CP）, 21 were patients with CP （group CP）, 21 were patients with PE （group PE） and 21 were healthy volunteers （group H）. The periodontal indexes such as PI, PD, AL and BOP were recorded and the serum levels of TNF-α;IL-6, CRP were measured. Results The periodontal indexes including probing depth（PD）, attachment loss（AL） and bleeding on pro- bing（BOP） were significantly different among the four groups. In the （PE ＋ CP）, PE and CP groups, the serum levels of TNF-α, IL-6, CRP levels were significantly higher compared to those in the H group （ P 〈 0.05 ）. Furthermore, the TNF-α, IL-6, CRP levels were significantly higher in the（ PE ＋ CP）group than those in the PE and CP groups （P 〈 0.05）. Conclusion TNF-α; IL-6, CRP may be closely related to the pathogenesis of preeclampsia and chronic periodontitis. A certain correlation may exist between preeclampsia and chronic periodontitis.

关 键 词：牙周炎 子痫前期 肿瘤坏死因子-Α 白细胞介素-6 C-反应蛋白 

分 类 号：R781.4[医药卫生—口腔医学]