神经生长因子与糖尿病神经病变的研究进展  

Research Progress in NGF and Diabetic Neuropathy

作　　者：贾彩霞[1] 王元松[1] 田凤胜[1] 

机构地区：[1]河北省沧州中西医结合医院内分泌科,河北沧州061001

出　　处：《医学综述》2012年第19期3256-3259,共4页Medical Recapitulate

摘　　要：糖尿病神经病变是糖尿病常见并发症之一。神经生长因子(NGF)在糖尿病神经病变的发生和发展中发挥重要作用。NGF是一种信号分子,其生物活性受酪氨酸激酶受体A和p75神经营养因子受体的调节。NGF能调节中枢神经和外周神经的生存和生长,并且NGF能选择性地营养小神经纤维感觉神经元和交感神经元。在动物模型和临床研究中,均有证据表明NGF与糖尿病神经病变关系密切。研究NGF与糖尿病神经病变的关系将有助于为糖尿病神经病变的防治提供新的研究思路。Diabetic neuropathy is one of the common complications in diabetes, Nerve growth factor （NGF） is important in the oecuruence and development of diabetic neuropathy. NGF is a signal molecule the activity is regulated by tyrosine kinase receptor and p75 neurotrephin receptor. NGF can regulate central and periheral nerve growth and survival;and nerve growth factor can selectively nuture small nerve fibres sensory neurons and sympathetic neurons. In the anmial experiments and clinical studies,lots of evidence shows that NGF is closely related with diabetic neuropathy. It is useful to research the relationship between NGF and di- abetic neuropathy for new perspectives for prevention and treatment of diabetic neuropathy.

关 键 词：神经生长因子 糖尿病神经病变 受体 

分 类 号：R578.1[医药卫生—消化系统]