Improved Synthesis of Miriplatin  

作　　者：WANG Qingkun PU Shaoping LIU Zhudong LIU Liangmeng LIAO Yunxing JIN Ji 

机构地区：[1]Yunnan Engineering and Technology Center of Platinum-based Anti-tumor Drug,Kunming Guiyan Pharmaceutical Co.Ltd.,Kunming 650106,China

出　　处：《贵金属》2012年第A01期281-283,共3页Precious Metals

基　　金：The Yunnan science and technology project(2010DH021);Kunming Wuhua Zoon science and technology project(201037)

摘　　要：Miriplatin, a novel lipophilic platinum complex has been developed to treat hepatocellular carcinoma. An improvd synthetic route was designed and used to prepare the target compound. The intermediate Pt(C6H14N2)(I) 2 was synthesized from K 2 PtCl 4 , KI and (1R,2R)-1,2-cyclohexanediamine, Pt(C 6 H 14 N 2 )(I) 2 was reacted with AgNO 3 to prepare Pt(C 6 H 14 N 2 )(H 2 O) 2 (NO 3 ) 2 solution then was subsequently reacted with CH 3 (CH 2 ) 12 COONa in n-butanol to give target compound with satisfied yield 81%(based on Pt(C 6 H 14 N 2 )I 2 ). The structure of the target compound was identified by elemental analysis, ESI-MS, FT-IR, 1H-NMR, thermal analysis, the structure was consistent with the target compound.Miriplatin, a novel lipophilic platinum complex has been developed to treat hepatocellular carcinoma. An improvd synthetic route was designed and used to prepare the target compound. The intermediate Pt（C6H14N2）（I）2 was synthesized from K2PtC14, KI and （1R,2R）-1,2-cyclohexanediamine, Pt（C6H14N2）（I）2 was reacted with AgNO3 to prepare Pt（C6H14N2）（H20）2（NO3）2 solution then was subsequently reacted with CH3（CH2）12COONa in n-butanol to give target compound with satisfied yield 81%（based on Pt（C6H14N2）I2）. The structure of the target compound was identified by elemental analysis, ESI-MS, FT-IR, 1H-NMR, thermal analysis, the structure was consistent with the target compound.

关 键 词：antitumor drug MIRIPLATIN improved synthesis 

分 类 号：O614.836[理学—无机化学]