MIRIPLATIN

作品数：7被引量：8H指数：2
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相关领域：医药卫生更多>>
相关作者：王利华陈常青赵丽嘉更多>>
相关机构：天津市医药集团有限公司天津药物研究院更多>>
相关期刊：《国外药讯》《World Journal of Radiology》《药物评价研究》《Open Journal of Radiology》更多>>
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Nanomedicine integrating the lipidic derivative of 5-fluorouracil,miriplatin and PD-L1 si RNA for enhancing tumor therapy
《Chinese Chemical Letters》2024年第6期385-391,共7页An Lu Yuhao Guo Yi Yan Lin Zhai Xiangyu Wang Weiran Cao Zijie Li Zhixia Zhao Yujie Shi Yuanjun Zhu Xiaoyan Liu Huining He Zhiyu Wang Jian-Cheng Wang 
financial support from the Basic Research Cooperation Project of Beijing,Tianjin,Hebei from the Natural Science Foundation of Beijing(No.J200018),Tianjin(No.20JCZXJC00070),and Hebei(No.H2020206649);Beijing Natural Science Foundation(No.7214281);the projects of National Natural Science Foundation of China(No.81973259)。
Immunosuppressive microenvironments present critical problems in clinical chemotherapy.To regulate the tumor immune microenvironment for enhancing antitumor effect,a combination of immune checkpoint inhibitors(ICIs)wi...
关键词：CHEMO-IMMUNOTHERAPY Immune checkpoint inhibition Gene silencing MIRIPLATIN Macrophage phagocytosis Nanotechnology 
Miriplatin-loaded liposome,as a novel mitophagy inducer,suppresses pancreatic cancer proliferation through blocking POLG and TFAM-mediated mtDNA replication被引量：3
《Acta Pharmaceutica Sinica B》2023年第11期4477-4501,共25页Xiaowei Wang Mengyan Wang Meilian Cai Rongguang Shao Guimin Xia Wuli Zhao 
supported by grants from CAMS Innovation Fund for Medical Sciences (CIFMS) (2022-I2M-2-002,2021-I2M-1030,China);National Natural Science Foundation of China (No.81473249 and 81102464);Drug Innovation Major Project of China (2018ZX09711001-007-002);National Key Research and Development Program of China (2016YFA0201504);National Mega-project for Innovative Drugs (2014ZX09201042,China)。
Pancreatic cancer is a more aggressive and refractory malignancy.Resistance and toxicity limit drug efficacy.Herein,we report a lower toxic and higher effective miriplatin(MPt)-loaded liposome,LMPt,exhibiting totally ...
关键词：Miriplatin-loaded liposome Pancreatic cancer Caveolae-mediated endocytosis Caveolin-1 MITOPHAGY Mitochondria DNA POLG TFAM 
Effects of Transcatheter Arterial Chemoembolization for Unresectable Hepatocellular Carcinoma Using a Combination of Platinum Agents (Cisplatin plus Miriplatin): A Retrospective Comparison with Cisplatin Monotherapy被引量：1
《Open Journal of Radiology》2018年第4期260-273,共14页Koichi Hamada Satoshi Saitoh Shigeki Imai Noriyuki Nishino Yoshinori Horikawa Michitaka Honda 
Background: Miriplatin is a slow-release, lipophilic platinum complex, developed to produce a superior antitumor effect for hepatocellular carcinoma (HCC). However, the miriplatin suspension is highly viscous and can ...
关键词：Hepatocellular Carcinoma TRANSCATHETER Arterial CHEMOEMBOLIZATION MIRIPLATIN CISPLATIN 
Improved Synthesis of Miriplatin
《贵金属》2012年第A01期281-283,共3页WANG Qingkun PU Shaoping LIU Zhudong LIU Liangmeng LIAO Yunxing JIN Ji 
The Yunnan science and technology project(2010DH021);Kunming Wuhua Zoon science and technology project(201037)
Miriplatin, a novel lipophilic platinum complex has been developed to treat hepatocellular carcinoma. An improvd synthetic route was designed and used to prepare the target compound. The intermediate Pt(C6H14N2)(I) 2 ...
关键词：antitumor drug MIRIPLATIN improved synthesis 
Transarterial chemoembolization with miriplatin-lipiodol emulsion for neuroendocrine metastases of the liver被引量：2
《World Journal of Radiology》2010年第12期468-471,共4页Jin Iwazawa Shoichi Ohue Keigo Yasumasa Takashi Mitani 
Miriplatin,a cisplatin derivative with a high affinity for iodized oil,is a novel chemotherapeutic agent designed for use in the transarterial treatment of hepatocellular carcinoma.This case report describes our exper...
关键词：CHEMOEMBOLIZATION LIVER Metastatic TUMOR MIRIPLATIN NEUROENDOCRINE TUMOR 
脂溶性铂复合物抗癌药——Miriplatin Hydrate被引量：2
《药物评价研究》2010年第4期323-326,共4页王利华 赵丽嘉 陈常青 
Miriplatin Hydrate是大日本住友制药株式会社开发的脂溶性铂复合物抗癌药,商品名：Miripla,化学名：（SP-4-2）-[（1R,2R）-1,2环己二氨-N,N′]二（十四酸-O）合铂,CAS登记号：141977-79-9,结构式见图1,分子式C34H68N2O4Pt·H2O，相...
关键词：MIRIPLATIN HYDRATE 脂溶性铂复合物抗癌药 肝细胞癌 
Miriplatin接近获得全球首次批准
《国外药讯》2009年第10期21-21,共1页
日本药品和食品卫生理事会的一个评审委员会推荐批准大日本住友公司的Miripla（miriplatin）用于肝细胞癌（HCC）的治疗。同时获得肯定推荐的有ToaYakushin公司的万古霉素（vancomycin）眼科软膏配方，用于范围广泛的眼科感染。这2个产...
关键词：眼科感染 评审委员会 肝细胞癌 食品卫生 软膏配方 万古霉素 世界范围 理事会 
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