CHEMO-IMMUNOTHERAPY

作品数：28被引量：76H指数：5
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相关领域：医药卫生更多>>
相关机构：南方医科大学南方医院深圳市人民医院更多>>
相关期刊：《Science China(Technological Sciences)》《Nano-Micro Letters》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金中国博士后科学基金湖北省自然科学基金更多>>
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A GSH-Responsive Immune-Stimulating Polypeptide Hydrogel Loaded with Chemotherapeutics,IDO Inhibitor and Immune Checkpoint Blocking Antibody for Enhanced Anti-Tumor Chemo-Immunotherapy
《Chinese Journal of Chemistry》2024年第23期2957-2969,共13页Junfeng Ding Tianran Wang Yan Rong Chaoliang He Xuesi Chen 
financially supported by the National Natural Science Foundation of China(Projects 52173147,52203202,51973218);the Scientific and Technological Development Projects of Jilin Province(20240202002GX).
Due to the immunosuppressive tumor microenvironment(TME),T cells are usually inactivated and tend to differentiate into regulatory T cells(Tregs)in the tumor tissues,which seriously hinders the anti-tumor efficiency o...
关键词：Immune-stimulating hydrogel POLYPEPTIDE Stimuli-responsive Immunotherapy Immunosuppressive microenvironment Cancertreatment Drug delivery 
Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer
《Acta Pharmaceutica Sinica B》2024年第11期4977-4993,共17页Mengya Niu Yihan Pei Tiantian Jin Junxiu Li Liming Bai Cuixia Zheng Qingling Song Hongjuan Zhao Yun Zhang Lei Wang 
National Natural Science Foundation of China(Nos.82171333,82272847,82202318);Postdoctoral Fellowship Program of CPSF(GZB20230675,China);The Henan Province Fund for Cultivating Advantageous Disciplines(No.222301420012,China);Central Plains Science and Technology Innovation Leading Talent Project(No.234200510005,China);Graduate Education Reform Project of Henan Province(2023SJGLX127Y,China).
A colon-specific drug delivery system has great potential for the oral administration of colorectal cancer.However,the uncontrollable in vivo fate of liposomes makes their effectiveness for colonic location,and intrat...
关键词：Colorectal cancer Colon-specific delivery Oral liposomes OXALIPLATIN Intratumoral bacteria CHEMO-IMMUNOTHERAPY Clostridium butyricum spores Gut microbiota 
Mitochondrial metabolism blockade nanoadjuvant reversed immune-resistance microenvironment to sensitize albumin-bound paclitaxel-based chemo-immunotherapy
《Acta Pharmaceutica Sinica B》2024年第9期4087-4101,共15页Zaigang Zhou Wenjuan Luo Chunjuan Zheng Haoxiang Wang Rui Hu Hui Deng Jianliang Shen 
the National Natural Science Foundation of China(22377093);the Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholar(LR23C100001,China);the Zhejiang Qianjiang Talent Plan(QJD20020224,China).
Currently, the efficacy of albumin-bound paclitaxel (PTX@Alb) is still limited due to theimpaired PTX@Alb accumulation in tumors partly mediated by the dense collagen distribution. Meanwhile,acquired immune resistance...
关键词：CHEMO-IMMUNOTHERAPY Collagen Transforming growth factor-b Mitochondrial metabolism Programmed cell deathligand 1 Drug accumulation Albumin-bound paclitaxel Immune-resistance microenvironment 
PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel
《Particuology》2024年第8期280-290,共11页Yan Wang Feng Li Shuang Wang Jiaqi Meng Xiao Zhang Wei Wei 
Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the clinic.However,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T c...
关键词：PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death CHEMO-IMMUNOTHERAPY 
Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy
《BMEMat(BioMedical Engineering Materials)》2024年第2期118-133,共16页Guiqiang Zhang Ning Wang Yuan Ma Shumei Zhai To Ngai Shilei Ni Xinyi Jiang Jianwei Jiao Jiwei Cui 
Shandong Traditional Chinese Medicine Technology Project,Grant/Award Number:Q-2023127;Innovation Project of Jinan Science and Technology Bureau,Grant/Award Number:2020GXRC022;Project for Scientific Research Innovation Team of Young Scholars in Colleges and Universities of Shandong Province,Grant/Award Numbers:2020KJC001,2022KJ196;National Natural Science Foundation of China,Grant/Award Number:22372091;Natural Science Foundation of Shandong Province,Grant/Award Number:ZR2023MB081。
Activating the stimulator of interferon genes(STING)signaling pathway is critical for enhancing antitumor immunity and remodeling the immunosuppressive tumor microenvironment(TME).Herein,we report the preparation of S...
关键词：amino acid metabolism immunotherapy NANOPARTICLES self-assembly STING 
Nanomedicine integrating the lipidic derivative of 5-fluorouracil,miriplatin and PD-L1 si RNA for enhancing tumor therapy
《Chinese Chemical Letters》2024年第6期385-391,共7页An Lu Yuhao Guo Yi Yan Lin Zhai Xiangyu Wang Weiran Cao Zijie Li Zhixia Zhao Yujie Shi Yuanjun Zhu Xiaoyan Liu Huining He Zhiyu Wang Jian-Cheng Wang 
financial support from the Basic Research Cooperation Project of Beijing,Tianjin,Hebei from the Natural Science Foundation of Beijing(No.J200018),Tianjin(No.20JCZXJC00070),and Hebei(No.H2020206649);Beijing Natural Science Foundation(No.7214281);the projects of National Natural Science Foundation of China(No.81973259)。
Immunosuppressive microenvironments present critical problems in clinical chemotherapy.To regulate the tumor immune microenvironment for enhancing antitumor effect,a combination of immune checkpoint inhibitors(ICIs)wi...
关键词：CHEMO-IMMUNOTHERAPY Immune checkpoint inhibition Gene silencing MIRIPLATIN Macrophage phagocytosis Nanotechnology 
Acidic/hypoxia dual-alleviated nanoregulators for enhanced treatment of tumor chemo-immunotherapy
《Asian Journal of Pharmaceutical Sciences》2024年第2期136-152,共17页Xiaoju Guo Xiaoxiao Chen Jiayi Ding Feng Zhang Shunyang Chen Xin Hu Shiji Fang Lin Shen Chenying Lu Zhongwei Zhao Jianfei Tu Gaofeng Shu Minjiang Chen Jiansong Ji 
supported by the Key R&D Program of Lishui City(2021ZDYF12,2022ZDYF07,2023zdyf14);Natural Science Foundation of China(82072026,82072025 and 82272090);Zhejiang Provincial Natural Science Foundation(LY23H180003,LQ22H180010);Provincial and Ministerial Joint Construction of Key Projects(WKJ-ZJ-2317).
Chemotherapy plays a crucial role in triple-negative breast cancer (TNBC) treatment as it not only directly kills cancer cells but also induces immunogenic cell death. However, the chemotherapeutic efficacy was strong...
关键词：CaCO3-based nanoparticles Hypoxia attenuation Acidity neutralization Reversal of chemotherapy resistance Enhanced chemo-immunotherapy 
Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis via mitochondrial membrane remodeling for synergistic chemo-immunotherapy被引量：1
《Acta Pharmaceutica Sinica B》2024年第4期1742-1758,共17页Renming Fan Ruizhuo Lin Shuo Zhang Aohua Deng Yongrui Hai Junyan Zhuang Yang Liu Maosheng Cheng Gaofei Wei 
This work was supported by the National Natural Science Foundation of China(82173682,China);Shenzhen Science and Technology Program(JCYJ20210324133213037,China);Innovation Capability Support Program of Shaanxi(2021KJXX-92,China)。
Mitochondrial membrane remodeling can trigger the release of mitochondrial DNA (mtDNA), leading to the activation of cellular oxidative stress and immune responses. While the role of mitochondrial membrane remodeling ...
关键词：Anti-tumor drug PRODRUG Platinum CHEMO-IMMUNOTHERAPY Mitochondrial membrane modeling STING PYROPTOSIS mtDNA 
Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors被引量：1
《Nano Research》2024年第2期836-847,共12页Shuping Li Xin Li Jiaqi Meng Weier Bao Shuang Wang Peng Ye Xiao-Dong Gao Wei Wei 
supported by the Beijing Natural Science Foundation(No.JQ21027);the National Natural Science Foundation of China(Nos.U2001224,32030062,21821005,and 82202028).
Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver drugs.However,the severe systemic inflammatory response trig...
关键词：outer membrane vesicles DOXORUBICIN tumor microenvironment IMMUNOTHERAPY CHEMOTHERAPY 
Chemo-immunotherapy by dual-enzyme responsive peptide self-assembling abolish melanoma被引量：1
《Bioactive Materials》2024年第1期549-562,共14页Yuhan Wang Limin Xie Xinxin Li Ling Wang Zhimou Yang 
supported by the National Key Research and Development Program of China(2022YFB3804600);the National Natural Science Foundation of China(32171325,32301122 and 82261160656).
Herein,we designed Comp.1 to simultaneously respond to two enzymes:alkaline phosphatase and matrix metalloproteinase 2,which is commonly found in highly malignant cancer cell lines containing B16-F10 murine melanoma c...
关键词：Self-assembly Dual-enzyme responsive CHEMO-IMMUNOTHERAPY Procedural delivery Anti-tumor 
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