再住院精神分裂症患者的药物维持治疗状况及影响因素  

Situation and Related Factors of Maintenance Medication Treatment in Schizophrenic Patients Re-hospitalized for Relapse

作　　者：张大光[1] 顾小静[1] 唐利荣[1] 郭俊花[1] 王久英[1] 马辛[1] 吴淑华[1] 蔡璐[1] 晁为铭[1] 黄青[1] 翁永振[1] 张文强[1] 封砚村[1] 向应强[1] 

机构地区：[1]首都医科大学附属北京安定医院,北京市100088

出　　处：《中国康复理论与实践》2012年第9期858-860,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：北京市教育委员会科技发展计划项目(KM200910025024);北京市科技计划课题(D101107047810004)

摘　　要：目的探讨因病情复发再住院的精神分裂症患者药物维持治疗状况及影响其药物维持治疗时间的相关因素。方法用影响药物维持治疗相关因素调查表,对362例复发住院的精神分裂症患者及其家属进行调查。结果 2年内自行停药者约占63.8%,自行停药与低量维持者之和约占84.9%,约7.7%的患者足量服药维持治疗。Logistic回归分析显示,自知力(OR=2.2144,P=0.001)、家庭照管(OR=4.8842,P=0.025)、出院疗效(OR=2.2056,P=0.007)、负性生活事件(OR=0.4529,P=0.003)是药物维持治疗时间的相关因素。结论精神分裂症患者出院后常因疾病自知力差、家庭照管能力不足、住院时治疗效果不好和负性生活事件影响而自行减药或停药,导致疾病复发再住院。Objective To survey the situation and related factors of maintenance medication treatment in schizophrenic patients re-hospitalized for relapse.Methods 362 patients re-admitted with schizophrenia and their relatives were interviewed with questionnaire which included 16 factors that might affect maintenance medication treatment.Results 63.8% patients stopped medication and 21.1% patients were on low-dose maintenance medication treatment by themselves,while 7.7% patients were on reasonable dose anti-psychotics in 2 years.The time of maintenance medication treatment related with insight（OR=2.2144,P=0.001）,family care（OR=4.8842,P=0.025）,outcomes of treatment（OR=2.2056,P=0.007） and negative life events（OR=0.4529,P=0.003）.Conclusion Schizophrenic patients re-admitted with relapse often withdraw or reduce their medication by themselves,which risked with poor insight,poor therapeutic effect,poor care from their family,and more negative life events.

关 键 词：精神分裂症 复发 再住院 药物维持治疗 

分 类 号：R749.3[医药卫生—神经病学与精神病学]