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作 者:王凤龙[1] 周林玉[1] 谈宜傲[1] 王子夜 王辰[1] 谢金波[1]
机构地区:[1]安徽医科大学附属省立医院泌尿外科,安徽合肥230001
出 处:《安徽医药》2012年第11期1617-1618,共2页Anhui Medical and Pharmaceutical Journal
摘 要:目的探讨存活蛋白(Livin)在肾透明细胞癌(RCCC)组织中的表达及意义。方法采用免疫组化的方法对63例RCCC组织和38例正常肾组织中Livin的表达进行检测。分析它的表达变化与RCCC肿瘤大小,临床分期,病理分级及淋巴结转移的关系。结果 Livin在RCCC组织中的表达阳性率明显高于正常肾组织(P<0.05),并与肿瘤大小有关(P<0.05)。有淋巴结转移者明显高于无淋巴结转移者(P<0.05),并且随着临床分期增加其表达亦明显增高(P<0.05),与病理分级无关(P>0.05)。结论 Livin在RCCC组织中表达明显上调,并且与肿瘤的大小,临床分期及淋巴结转移密切相关。Objective To explore the expression of Livin and its significance in clear cell carcinoma of kidney. Methods The expres sion of Livin was examined by immunohistochemistry in 63 cases of clear cell carcinoma of kidney, 38 cases of normal renal tissues. Re sults of Livin expression were compared with tumor size, clinical stage, pathology grade and lymphatic metastasis to make the correlation analysis. Results The positive rate of Livin expression was obviously higher in RCCC specimens than in normal renal tissues ( P 〈 0. 05 ), and correlated with tumor size ( P 〈 0.05 ) , but independent of pathology grade ( P 〉 0.05 ). It was higher in clear cell carcinoma of kidney with lymphatic metastasis than without ( P 〈 0.05 ) , With the increase of clinical stage, the expression of OPN showed heighte ning in corresponding ( P 〈 0.05 ). Conclusion Livin was highly expressed in RCCC specimens and closely correlated with tumor size, clinical sta^e and lymphatic metastasis.
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