小剂量罗库溴胺预处理抑制无抽搐电休克中肌颤和肌痛的临床观察  

Clinical study on small dose rocuronium bromide pretreatment reducing the muscle fasciculation and myalgia treated by modified electroconvulsive therapy

作　　者：王晓静 解凤娥 

机构地区：[1]徐州矿务集团第一医院麻醉科,江苏徐州221131

出　　处：《中国医药科学》2012年第19期63-64,共2页China Medicine And Pharmacy

摘　　要：目的观察小剂量罗库溴胺预处理对精神病患者无抽搐电休克治疗肌颤和肌痛的影响。方法选择于笔者所在医院行无抽搐电休克治疗患者80例,随机分为对照组(n=40)和干预组(n=40)。对照组在丙泊酚配伍琥珀胆碱麻醉下行MECT,观察患者肌颤情况、自主呼吸恢复时间、苏醒时间,并采用视觉模糊评分记录患者睁眼的即时、30min、6h的疼痛情况。干预组在麻醉前1min静脉注射罗库溴胺0.06mg/kg,其余治疗同对照组。结果比较血流动力学、自主呼吸恢复时间、苏醒时间,两组间差异无统计学意义(P>0.05),干预组肌颤发生率明显低于对照组,程度也明显减轻(P<0.05)。T1、T2时VAS小于对照组(P<0.05)。结论小剂量罗库溴胺预处理可有效抑制无抽搐电休克治疗中的肌颤和肌痛。Objective To investigate the influence of small dose rocuronium bromide pretreatment on the muscle fasciculation and myalgia treated by modified elect roconvulsive therapy. Methods A total of 80 psychotic patients were randomly divided into two groups： control group（n=40） and treatment group（n=40）. The patients in control group were performed by MECT after anesthetizing with propofol and suxamethonium intravenously. Awakening time, recovery time of spontaneously breathing and adverse reactions were recorded. The visual analogue scale at TO, T1 and T2 were recorded. At ＂the same time,the patients in treatment group were given additional rocuronium bromide 0.06 mg/kg one minute before anesthesia. Results There were no significant differences in recovery time of spontaneously breathing, awakening time between two groups （P 〉 0.05）. The incidence of muscle fasciculation in treatment group was significantly lower than that in control group. The degree of muscle fasciculation also significantly reduce （P 〈 0.05）. T1, T2 VAS when less than that in control group （P 〈 0.05）. Conclusion Small dose rocuronium bromide pretreatment can effectively relieve the muscle fasciculation and myalgia caused by MECT.

关 键 词：罗库溴胺 无抽搐电休克 肌颤 肌痛 琥珀胆碱 

分 类 号：R749.3[医药卫生—神经病学与精神病学]