幽门螺杆菌对脑梗死患者血小板活化及凝血功能的影响  

Effect of Helicobacter pylori infection on platelet activation and coagulation function in patients with acute cerebral infarction

作　　者：吴海琴[1] 汤燕[2] 张欣[3] 魏玄辉[1] 王虎清[1] 张文婷[1] 张桂莲[1] 

机构地区：[1]西安交通大学医学院第二附属医院神经内科,陕西西安710004 [2]西北工业大学校医院,陕西西安710072 [3]陕西省人民医院,陕西西安710032

出　　处：《浙江大学学报（医学版）》2012年第5期547-552,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：陕西省社发攻关资助项目(2009K16-02)

摘　　要：目的:观察幽门螺杆菌(Helicobacter pylori,Hp)感染对急性脑梗死患者血小板活化水平及凝血功能的影响,探讨其参与脑梗死发病的可能机制。方法:检测66例初发急性脑梗死患者(脑梗死组)和50例非脑血管病患者(对照组)Hp抗体浓度,全血血小板表面活化依赖的膜糖蛋白CD62p的表达和各凝血指标的水平,比较脑梗死组与对照组幽门螺杆菌感染情况、CD62p表达水平和凝血功能。结果:①脑梗死组Hp-IgG和Hp-CagA阳性率均高于对照组(P<0.05)。②脑梗死组Hp阳性患者血小板表面CD62p阳性率高于脑梗死组Hp阴性患者及对照组(P<0.05)。③脑梗死组Hp阳性患者PT、PTR及INR与Hp阴性组患者无明显差异(P>0.05),但两组间APTT、TT及FIB差异显著(P<0.05),其中Hp阳性患者APTT、TT较Hp阴性患者缩短,而FIB含量高于Hp阴性患者。结论:Hp感染可能通过增强急性脑梗死患者的血小板活化水平影响其凝血功能,参与脑梗死的发生与发展。Objective： To investigate the effect of Helicobacter pylori（Hp） on platelet activation and coagulation function in patients with acute cerebral infarction.Methods： Sixty-six patients with acute cerebral infarction and 50 health individuals were enrolled in the study.Hp antibody,expression of CD62p on platelets and clotting indexes were measured and compared between two groups.Results： The positive rate of Hp-IgG and Hp-CagA in cerebral infarction patients were higher than that in controls（P0.05）.The positive rate of CD62p in patients with positive Hp-IgG and Hp-CagA was significantly higher than that in negative patients and also controls（P0.05）.The APTT and TT were lower and FIB was higher in patients with positive Hp antibody than those in patients with negative Hp antibody（P0.05）,but there was no difference in PT,PTR and INR（P0.05）.Conclusions： Hp infection can activate platelets and affect coagulation function,which may be involved in the development of cerebral infarction.

关 键 词：螺杆菌 幽门 螺杆菌感染/病理生理学 脑梗死/病因学 脑梗死/微生物学 血小板活化 P选择素/血液 血液凝固 

分 类 号：R743.3[医药卫生—神经病学与精神病学]