Microwave assisted synthesis and in silico screening of steroidal pyrazolines  

作　　者：Mahboob Alam Shahab A.A.Nami M.Parveen Dong-Ung Lee Soonheum Park 

机构地区：[1]Division of Bioscience,Dongguk University,Gyeongju 780-714,Republic of Korea [2]Department of Chemistry,Aligarh Muslim University,Aligarh 202002,India [3]Department of Chemistry,Dongguk University,Gyeongju 780-714,Republic of Korea [4]Department of Kulliyat,Faculty of Unani Medicine,Aligarh Muslim University,Aligarh 202002,India

出　　处：《Chinese Chemical Letters》2012年第9期1039-1042,共4页中国化学快报（英文版）

摘　　要：The present manuscript describes solid-state synthesis of some reported steroidal pyrazolines by a novel eco-friendly route. The synthesized pyrazolines were compared with those obtained from conventional methods in terms of reaction time and overall yield. A substantial enhancement in reaction rate and yield was observed. The antimicrobial activity and the subsequent molecular docking studies of the steroidal pyrazolines have also been carried out.The present manuscript describes solid-state synthesis of some reported steroidal pyrazolines by a novel eco-friendly route. The synthesized pyrazolines were compared with those obtained from conventional methods in terms of reaction time and overall yield. A substantial enhancement in reaction rate and yield was observed. The antimicrobial activity and the subsequent molecular docking studies of the steroidal pyrazolines have also been carried out.

关 键 词：Solid state synthesis PYRAZOLINES In silico study Antimicrobial study 

分 类 号：O626[理学—有机化学]