小剂量5-FU持续滴注与小剂量PDD联合治疗晚期胃肠道癌35例临床观察  

Clinical Observation of Combined Treatment by Continuous Infusion of Low Dose 5-FU and Low Dose PDD in 35 Patients with Advanced Gastrointestinal Cancer

作　　者：沈波[1] 陆禹溶[1] 潘良熹[1] 郭仁宏[1] 

机构地区：[1]江苏省肿瘤医院内科,江苏南京210009

出　　处：《河南肿瘤学杂志》2000年第3期170-172,共3页Henan Journal of Oncology

摘　　要：目的　观察和分析小剂量氟脲嘧啶 (5 -FU)与小剂量顺铂 (PDD)联合治疗晚期胃肠道癌的临床疗效和毒副反应。方法　 35例中胃癌 2 2例 ,肠癌 13例。 5 -FU 2 0 0mg/m2 每天 ,持续静滴 3～ 4周 ;PDD 6mg/m2 每天 ,静滴 2小时 ,每周 5天 ,连用 3～ 4周。结果　无CR病例 ,PR17例 ,总有效率为 48 6 %。胃癌有效率为 5 4 6 % ,肠癌有效率为 38 5 % ,用过含 5 -FU方案治疗的患者有效率为43 8%。主要毒性反应为口腔炎、腹泻、恶心、呕吐。骨髓抑制轻 ,多为Ⅰ°～Ⅱ°。绝大多数患者能耐受该方案治疗。结论　作者认为该方案疗效好 ,毒副反应轻 ,治疗费用少 ,便于开展 ,值得临床推广。Objective To observe and analyse the clinical curative effects and toxical effects of gastrointestinal cancer patients treated with low dose 5-FU and low dose PDD.Methods 22 cases of gastric cancer and 13 cases of intestinal cancer were employed.Continuous infusion of 5-FU 200 mg/m 2/day lasted 3～4 weeks,and infusion of PDD 6 mg/m 2/day,2 h/d,5d/w,which was used for 3～4 weeks.Results Gross efficiency rate was 48.6% with none of CR and 17 cases of PR.The efficiency rate of gastric cancer patients was 54.6%,of intestinal cancer patients 38.5%,and of patients with previous chemotherapy consisting of 5-FU 43.8%.Major toxical effects were stomatitis,diarrhea,nausea and vomiting.Repression of marrow was light,much of it was Ⅰ°～Ⅱ°.Most of the patients can endure the toxicity of this chemothrapy.Conclusion The chemotherapy above had good curative and less toxical effects and less charge of treatment.It is worthy of further research and expansion in clinical practice.

关 键 词：持续滴注 氟脲嘧啶 顺铂 晚期胃肠道癌 治疗 

分 类 号：R735.205[医药卫生—肿瘤]