CagA阳性幽门螺杆菌感染与胃癌相关性探讨  

INVESTIGATION OF THE RELATIONSHIP BETWEEN CagA POSITIVE HELICOBACTER PYLORI AND GASTRIC CANCER

作　　者：关劼[1] 夏兴洲[2] 樊艳华[1] 邱林[3] 卢家罄 丛笑[3] 

机构地区：[1]中日友好医院消化科,北京100029 [2]郑州铁路局中心医院,郑州450000 [3]中日友好医院临床医学研究所免疫室,北京100029

出　　处：《中日友好医院学报》2000年第2期67-70,共4页Journal of China-Japan Friendship Hospital

基　　金：卫生部部级课题!98 2 0 40

摘　　要：目的 :探讨幽门螺杆菌 (HP)细胞表达相关抗原阳性 (CagA+)与胃癌的相关性及胃癌发生机制。方法 :选取胃癌 38例、萎缩性胃炎 30例、正常对照 2 4例。应用ELISA法检测血清HPCagA抗体 ,PCR法、组织学方法检测HP感染率 ,同时检测了癌旁组织HP感染率。根据Lauren分型将胃癌组分为肠型 ( 68 4% )和弥散型 ( 31 6% )。结果 :胃癌组CagA+( 50 0 % )明显高于正常对照组 ( 4 1 7% ) (P <0 0 5)。肠型CagA+( 61 5% )显著高于弥散型 ( 2 5 0 % ) (P <0 0 5)。癌旁组织HP感染率 ( 63 2 % )高于癌组织HP感染率( 55 3% )。结论 :萎缩性胃炎及胃癌发生可能与CagA+菌株感染有关。Objective:To study the relationship between cagA positive helicobacter pylori(HP) and gastric cancer(GC) and the pathogenesis of GC.Methods:Thirty eight GC patients include 26 intestinal and 12 diffused type GC patients,compared with 30 chronic atrophic gastritis(CAG) patients and 24 health control were studied.ELISA was carried out to detect serum IgG anti cagA antigen,and PCR and Giemsa stain were used to detect HP in gastric specimens from cancer area and from its surrounding mucosa.Results:The cagA positive rate in GC group was 50 0%,compared to 41 7% in the control group( P <0 05),and in the intestinal type GC the rate(61 5%) was higher than in the diffused type GC(25 0%)( P <0 05).HP infected rate in cancer area(55 3%) was slightly lower than that in its surrounding mucosa(63 2%).Conclusion:CAG and the development of GC seems to be related with CagA positive HP.

关 键 词：幽门螺杆菌 胃肿瘤 感染 病理 

分 类 号：R735.2[医药卫生—肿瘤]