中草药治疗银屑病致药物性肝病34例临床分析  

Liver disease induced by treatment of psoriasis with Chinese herbal medicine: An analysis of 34 cases

作　　者：王开利[1] 赵军[1] 邢汉前[1] 赵鸿[1] 刘俊薇[1] 陈阳[1] 

机构地区：[1]解放军第302医院血液净化科,北京100039

出　　处：《军医进修学院学报》2012年第10期1059-1060,1063,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的分析中草药治疗银屑病所致药物性肝病的临床特点,提高对药物性肝病的认识。方法回顾性总结我院收治的34例中草药治疗银屑病所致药物性肝病患者临床资料,对损肝药物、临床特点、并发症及预后等方面进行分析。结果 34例患者临床主要症状多表现为乏力、纳差、恶心、尿液发黄;实验室检查可有谷丙转氨酶(ALT)、血清总胆红素(TB)升高、凝血酶原活动度降低表现。所致药物性肝病以药物性肝炎常见,占67.6%,肝硬化占26.5%,肝衰竭占5.9%,常见并发症有腹水、电解质紊乱、原发性腹膜炎、胸腔积液、肝性脑病、上消化道出血。本组患者死亡率为2.9%。结论中草药治疗银屑病所致药物性肝病临床并不少见,长期服用可致肝硬化,重者可导致肝衰竭甚至死亡,用药过程中应密切监测肝功能。Objective To improve our understanding of liver diseases induced by treatment of psoriasis with Chinese herbal medicine by analyzing its clinical features.Methods Clinical data about 34 patients with drug liver disease induced by treatment of psoriasis with Chinese herbal medicine were retrospectively analyzed,including liver-damaging drugs,clinical features,complications and prognosis.Results The main clinical symptoms of the patients in this study were fatigue,anorexia,nausea,yellow urine.Laboratory tests showed that the alanine aminotransferase（ALT） and total bilirubin（TB） increased while the prothrombin activity decreased in these patients.Liver diseases induced by treatment of psoriasis with traditional Chinese medicine included hepatitis（67.6%）,cirrhosis（26.5%） and liver failure（5.9%）.The common complications were ascites,electrolyte imbalance,primary peritonitis,pleural effusion,hepatic encephalopathy,upper gastrointestinal bleeding.The mortality of patients in this study was 2.9%.Conclusion Liver diseases induced by treatment of psoriasis with Chinese herbal medicine are not uncommon.Long-term use of Chinese herbal medicine can lead to cirrhosis,liver failure and even death.Liver function should be closely monitored during treatment.

关 键 词：银屑病 中草药 药物性肝病 肝衰竭 

分 类 号：R575.5[医药卫生—消化系统]