无溶剂条件下简单、有效的合成多取代环己醇  

A Facile and Efficient Synthesis of Polysubstituted Cyclohexanol Derivatives under Solvent-Free Conditions

作　　者：荣良策[1,2] 魏贤勇[1] 路瑶[1] 宗志敏[1] 

机构地区：[1]中国矿业大学化工学院,徐州221008 [2]江苏师范大学化学化工学院,徐州221116

出　　处：《有机化学》2012年第10期1999-2002,共4页Chinese Journal of Organic Chemistry

基　　金：江苏省高校自然科学基础研究基金(No.08KJB150017);江苏师范大学科研平台(No.10XLS02)资助项目~~

摘　　要：取代苯乙酮与查尔酮在氢氧化钠存在下于70℃加热反应,取代苯乙酮与两分子查尔酮发生加成和环化反应,生成了多取代环己醇.本方法具有反应时间短、容易操作、产率高和环境友好等优点.产物的结构经过红外、核磁和元素分析确定,无溶剂方法是合成此类化合物的一条有效途径.A facile and efficient synthesis ofpolysubstituted cyclohexanol derivatives by the addition and cyclization reaction of substituted acetophenone and chalcone in the presence of NaOH under solvent-free conditions is reported. This protocol has the advantages of shorter reaction time, mild conditions, easy work-up, and environmental friendliness. The products were identified by IR, 1H NMR and elemental analysis. The so/vent-free method is the efficient approach for the synthesis of these compounds.

关 键 词：查尔酮 环己醇 无溶剂反应 迈克尔加成反应 羟醛缩合 

分 类 号：TQ233.1[化学工程—有机化工]