RegⅣ在结肠癌中的表达及其与结肠癌发生发展的关系  

Relationship between RegⅣ expression and the development of colon carcinoma

作　　者：周超[1,2] 汤礼军[2] 周福荣[3] 孙建鹰[3] 

机构地区：[1]泸州医学院临床医学院,四川泸州646000 [2]成都军区总医院全军普外中心,四川成都610083 [3]成都市第六人民医院,四川成都610051

出　　处：《四川医学》2012年第9期1533-1535,共3页Sichuan Medical Journal

摘　　要：目的研究正常组织和结肠癌组织中RegⅣ蛋白的表达,探讨其与结肠癌的发生发展关系。方法采用SABC免疫组织化学法分析102例结肠癌组织及50例正常结肠黏膜中RegⅣ表达,结合临床病理资料采用检验进行统计学分析,并做RegⅣ表达与结肠癌临床分期的回归分析,探讨RegⅣ与结肠癌的表达及发生发展的关系。结果正常结肠粘膜中RegⅣ无表达,结肠癌组织中RegⅣ阳性表达率为34.31%。其中,G1、G2和G3期结肠癌阳性率分别为0.00%、22.22%和68.66%,病理分级间比较差异具有统计学意义(P<0.05);临床分期的阳性率分别为T0(0.00%)、T1(33.33%)、T2(44.44%)、T3(52.38%)、T4(71.42%),各期间比较差异有统计学意义(P<0.05),两者回归方程为Y=5.955+15.83x,相关系数r=0.973。结论 RegⅣ在结肠癌的高表达与其病理分级及临床分期有密切的关系,可作为判断结肠癌分化程度的一个指标。Objective To explore the expression of colon carcinoma and the development relationship between Reg Ⅳ and colon carcinoma. Methods Expression of Reg Ⅳ in colon carcinoma was determined in 102 cases of colon carcinoma tissues and 50 normal mucous membrane of colon eases with SABC immunohistoehemieal method and clinic-pathological data of patients were collected and used to make statistical analysis. And we do the regression analysis of clinical stage of colon cancer and Reg Ⅳ expression to find their relationship. Results The positive rate of Reg Ⅳ expression was 34. 31% in 102 colon carcinoma tissues, but no expression of Reg Ⅳ in the normal colon tissue. The percentages of the positive cases for Reg Ⅳ were 0. 00%, 22. 22% , 68. 66% in pathological grades from grade one to grade three respectively （ P 〈 0. 05 ）. The percentages of the positive cases for Reg Ⅳ clinic stages of Ta,were T0（0. 00% ）, T1 （33. 33% ） ,T2（44. 44% ） , T3（52. 38% ）, T4（71.42% ） respectively （ P 〈 0. 05）. The regression equation between clinical stage of colon cancer and Reg Ⅳ is Y =5. 955 ＋ 15.83x, and the correlation co- efficient r = 0. 973. Conclusion High expression of Reg Ⅳ in colon carcinoma was positively related to the pathologic grade and the clinic stage of tumor, which might be a valuable maker for the character of colon carcinoma.

关 键 词：REG Ⅳ 结肠癌 免疫组织化学 

分 类 号：R735.35[医药卫生—肿瘤]