基于多阶段动态PCA的发酵过程故障监测  

Fault Detetion for Fermentation Process Based on Multiphase Dynamic PCA

作　　者：齐咏生[1,2] 王普[1] 高学金[1] 陈修哲[1] 

机构地区：[1]北京工业大学电子信息与控制工程学院,北京100124 [2]内蒙古工业大学电力学院,呼和浩特010051

出　　处：《北京工业大学学报》2012年第10期1474-1481,共8页Journal of Beijing University of Technology

基　　金：国家自然科学基金资助项目(61174109);内蒙古工业大学科学研究项目(ZS0201037)

摘　　要：针对间隙发酵过程具有多阶段、批次不等长,且过程动态非线性往往与发酵阶段密切相关等特点,提出一种基于多阶段动态主元分析(principal component analysis,PCA)的故障监测策略.该方法采用高斯混合模型(Gaussian mixture model,GMM)对过程数据进行聚类,能客观反映不同阶段操作模态的数据分布特点,可实现子阶段划分.针对各批次阶段划分后存在的不同步问题,采用动态时间错位(dynamic time warping,DTW)方法对各阶段进行轨迹同步,对同步后的子阶段建立动态PCA模型.最后以工业青霉素发酵过程和重组大肠杆菌制备白介素-2发酵过程为背景,采用多阶段动态PCA策略对其进行故障监测,发现算法能有效降低运行过程的漏报和误报率,验证了算法的有效性。In industrial manufacturing,most fermentation processes are inherently multiphase and uneven-length batch processes in nature.Based on different dynamic nonlinear characteristics of different fermentation phases,a new strategy is proposed by using multi-phase dynamic principal component analysis（PCA） for fermentation process monitoring.Using Gaussian mixture model（GMM） clustering arithmetic,fermentation process data are divided into several operation stages,since GMM is adopted to discriminate different operation modes.Then,run-to-run variations among different instances of a phase are synchronized by using dynamic time warping（DTW）,and sub-phase dynamic PCA models are developed for every phase.Finally,the proposed method is applied to monitor both the industrial processes of fed-batch penicillin production and interleukin-2 production in recombinant E.coli.Results demonstrate that fewer false alarms and small fault detection delay are obtained and the algorithm is proved to be efficient.

关 键 词：发酵过程 动态时间错位 高斯混合模型 主元分析 

分 类 号：TP274.5[自动化与计算机技术—检测技术与自动化装置]