孤独症谱系障碍儿童的临床药物治疗研究进展  

Progress in clinical effect of medication for child with autism spectrum disorders

作　　者：王冬青[1] 张嵘[1] 

机构地区：[1]北京大学神经科学研究所,北京100191

出　　处：《中国临床药理学杂志》2012年第9期698-700,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家基础科学人才培养基金资助项目(30831/J0108);国家自然科学基金资助项目(30973832)

摘　　要：孤独症谱系障碍是婴儿期起病的一大类广泛性发育障碍。逐年增高的发病率、缺少有效治疗手段与不良的预后,使其成为国内外神经科学研究热点。临床治疗方法是行为治疗和药物治疗相结合。本文对近5年国内外孤独症药物治疗的临床研究进展(包括传统抗精神病药、非典型抗精神病药、抗癫痫药、选择性5-羟色胺再摄取抑制剂以及催产素等)、药理机制、临床疗效以及不良反应,进行了比较与归纳。Autism spectrum disorder（ASD） is a series of pervasive developmental disorders.Since the prevalence of ASD is increasing year by year with no effective treatment available and poor prognosis,it has become one of the most heated research fields of neuroscience in China and abroad.The most commonly used therapies of ASD are behavioral interventions combined with drug therapies.This review summarized the advances in drug therapy for childhood autism in the last 5 years.The drugs involved include conventional antipsychotic drugs,antiepileptic drugs,selective serotonin reuptake inhibitors and oxytocin etc.This review introduced and compared their pharmacological mechanisms,clinical applications and adverse effects.

关 键 词：抗精神病药物 抗癫痫药 催产素 孤独症 

分 类 号：R748[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]