实验性颈淋巴引流障碍对大鼠心血管调节功能的影响  

The Functional Alteration of Cardiovascular Regulation after Experimental Cervical Lymphatic Blockage in Rats

作　　者：房玉珍[1] 陈连壁[2] 夏作理[1] 杨明峰[1] 

机构地区：[1]泰山医学院附属医院微循环研究所,山东省泰安市271000 [2]山东医科大学生理教研室

出　　处：《中国微循环》2000年第2期88-90,共3页Journal of Chinese Microcirculation

摘　　要：目的对阻断颈部淋巴引流大鼠的心血管系统整体调节功能变化进行无创性评价。方法将Wistar大鼠分两组 :对照组(n=10)接受假手术;淋巴引流阻断组(n=10)结扎颈浅及颈深淋巴管并摘除淋巴结以造成淋巴性脑水肿。两组均在术后第7d进行正立位及倒立位倾斜应激试验 ,其间连续测定动脉血压、心率、Ⅱ导ECG、顶部EEG及其能量曲线等变化 ,并计算整体压力感受器反射灵敏度(BS)。部分动物阻断两侧颈总动脉 ,观察脑电图变化及窦弓反射引起的血压变化。结果对照组正立位初 ,动脉血压降低 ,尔后迅速恢复正常。倒立位初 ,动脉血压升高 ,但随后迅速回降。当阻断两侧颈总动脉血流时 ,动脉血压升高 ,EEG不变 ,淋巴组正立位及倒立位时大鼠动脉血压均持续显著低于正常水平 ,出现心律紊乱。BS减小。阻断两侧颈总动脉后动脉血压反而降低 ,脑电图变平坦 ,脑电能量曲线几乎减小至零。结论大鼠颈淋巴引流障碍 ,可导致心血管系统整体调节功能减弱 ,压力感受器灵敏度减小 ,易产生体位性低血压。Objective To investigate the alterations of regulatory function of the cardiovascular system after experimental cervical lymphatic blockage in rats with passive posture tilting stress test (PPTST).Methods Wistar rats were divided into control group (n=10) which accepted sham-operation and cervical lymphatic blockage group(CLB group,n=10),in which the cervical lymphatic vessels were blocked and lymphatic nodes were removed. In both groups 7 days after operation the regulatory function of cardiovascular system was determined with PPTST. PPTST included head-up stress test (HUST) and head-down stress test (HDST). During both tests the arterial blood pressure (BP) and heart rate (HR) were continuously recorded. The total baroreceptor reflex sensitivity (BS) was calculated. In 7 animals the response of EEG and BP to an incomplete cerebral isehemia was observed. Results In control group at the beginning of HUST, BP decreased, and then rapidly restored to normal level within 3 min. At the begining of HDST, BP was unchanged. HR was not altered. Within 3 min after incomplete cerebral ischemia EEG was unchanged and the BP was increased by a baroreceptor reflex. In CLB group both during HUST and HUST the BP falled markedly. In some animals arrhythmia occurred. BS greatly decreased. After blocking the blood flow in the carotid arteries the EEG almost decreased to zero. Conclusion Experimental cervical lymphatic blockage leads to disturbance of hemostasis of the cardiovascular regulation. The observed functional disorder of cardiovascular regulation may play a role in etiology and pathophysiology of the lymphostatic encephalopathy.

关 键 词：颈淋巴引流障碍 心血管调节功能 大鼠 

分 类 号：R364.1[医药卫生—病理学]