miR-205与肿瘤  

miR-205 and cancer

作　　者：侯新新[1] 赵萌[1] 张贵宇[1] 

机构地区：[1]山东大学齐鲁医院妇产科,济南250012

出　　处：《国际肿瘤学杂志》2012年第10期732-734,共3页Journal of International Oncology

基　　金：山东省科技攻关项目（2008GGl0002058）

摘　　要：miR-205在多种肿瘤中存在差异性表达，与肿瘤的发生发展及转移等过程密切相关。miR-205可通过与特定靶基因结合参与调控肿瘤细胞的增殖、分化、原位侵袭及远处转移等生物学行为。对miR．205的深入研究，有望对肿瘤的诊断、靶向治疗及预后等发挥重要作用。miR-205 is differentially expressed in tumor tissues and is closely related to tumorigenesis and tumor metastasis, miR-205 can regulate the biological behaviors of tumor cells such as cell proliferation, differentiation, in situ invasion and distant metastasis by post-transcriptional regulation through binding to targe- ted genes. Additionally, further research of miR-205 may be helpful for tumor diagnosis, targeted therapy and prognosis.

关 键 词：微RNAS 肿瘤 生物学标记 

分 类 号：R730.2[医药卫生—肿瘤]