Wnt信号通路抑制因子SOX17在肿瘤中的研究  

Wnt signaling pathway antagonist SOX17 in cancer

作　　者：崔素芬[1] 王志志[1] 张玲玲[1] 

机构地区：[1]扬州市第一人民医院妇产科,225012

出　　处：《国际肿瘤学杂志》2012年第10期735-737,共3页Journal of International Oncology

摘　　要：SOX17作为SOX转录因子超家族的一员，在进化过程中高度保守，对胚胎内胚层的形成具有重要作用。研究发现，SOX17基因启动子高甲基化可导致其表达沉默或减少，从而异常激活经典Wnt信号通路，在肿瘤的形成和进展中具有至关重要的作用。SOX17, a member of the SOX family of transcription factors, is conserved in many species and plays an important role in the formation of embryo endodenn. A number of studies have found that SOXI7 gene expression is silenced or decreased might be due to promoter hypermethylation, which plays a vital role in tumorigenesis and tumor progression, and may contribute to aberrant activation of canonical Wnt signaling path- way in several human malignant tumors.

关 键 词：肿瘤 SOX17蛋白 WNT信号通路 

分 类 号：R730.5[医药卫生—肿瘤]