甘丙肽在肿瘤发生发展中的作用  

Roles of galanin peptide in tumorigenesis and tumor progression

作　　者：隋玉梅[1] 方彭华[1] 史明仪[1] 卜平[1] 

机构地区：[1]扬州大学医学院生理研究室,225001

出　　处：《国际肿瘤学杂志》2012年第10期738-741,共4页Journal of International Oncology

摘　　要：甘丙肽（GAL）作为一种神经肽，广泛分布于中枢和外周神经系统及内分泌系统。目前已发现GAL及其受体存在于多种神经内分泌肿瘤组织和非神经内分泌肿瘤组织中，如嗜铬细胞瘤、鳞状细胞瘤、脑垂体腺瘤和胃肠癌等等。GAL及其受体参与多种肿瘤的发生发展过程，研究其在肿瘤发生发展过程中的作用，对于有目的性地诊断和治疗肿瘤有积极作用。Galanin is a peptide with wide-ranging effects, especially within the central, peripheral nervous system and endocrine system. Many tumors of neuroendocrine origin, and also an increasing number of non-neuroendocrine cancers, have been shown to express galanin and/or its receptors. Expression of galanin peptide has been detected in pheochromocytoma, squamous cell carcinoma, pituitary adenoma, gastrointestinal cancers and so on. Galanin peptide plays an important role in tumori-genesis and progression of many kinds of tumors. Therefore, studying the roles of galanin and its receptors are helpful for diagnosis and treatment of tumors.

关 键 词：甘丙肽 肿瘤 甘丙肽受体 

分 类 号：R730.2[医药卫生—肿瘤]