关节软骨缺损修复的研究进展  

Research progress in the repair of articular cartilage defects

作　　者：陈飞飞[1] 田清业[1] 张祚勇[1] 何正[1] 

机构地区：[1]中国人民解放军第八十九医院全军创伤骨科研究所,潍坊261021

出　　处：《中国骨与关节杂志》2012年第5期509-512,共4页Chinese Journal of Bone and Joint

摘　　要：高能量暴力外伤、关节内感染以及其他疾病能引起严重骨缺损，同时也导致关节软骨损伤。现在，关节软骨损伤已成为临床骨科医生面临的一大难题。由于体内关节软骨的自身修复能力极其有限，一旦损伤，很难自愈，常可致畸致残。对此，国内外学者做了大量研究，本文就关节软骨缺损的修复方法做一综述。Various causes which may lead to the defects of articular cartilage are very common in clinic. The regenerating capacity of cartilage tissue is limited, so it is hard to cure when it gets damaged. For the defects of articular cartilage, the present internal and external treatment methods are mainly sub-chondral drilling, micro-fracture, periosteum, perichondrium and other soft tissue transplantation, autologous or allogeneic bone cartilage transplantation and cartilage tissue engineering. In general, when the cartilage defect area is less than l.Ocm, drilling, micro-fracture surgery or periosteum and soft tissue transplantation can obtain satisfactory effect; but when the defect area is bigger than lcm or even bigger, autologous or allogeneic bone cartilage transplantation and cartilage tissue engineering method will be needed. Although a lot of methods have been used for the treatment of articular cartilage injury and diseases, and they have got certain effect in a short time. However, there is still no effective treatment method to ensure the long-term functional recovery of the articular cartilage. Sub-chondral drilling is a potential repairing method, but it also depends on age, the defect area and biological factors. And the success rate of the regeneration and restoration of cartilage surface layer to the functional state is very low. Although hyaline cartilage repair mode has got gratifying progress, but there is no effective therapeutic measure to restore the articular cartilage complicated biological, morphological, and mechanical properties. Articular cartilage is listed as highly organized tissue; however, the existing engineering cartilage culture system cannot distinguish the refined structure. The future development of cartilage repair should be focused on the principle, which means to design, construct and restore of the complicated function of articular cartilage based on tissue engineering, chemistry, biology and other life science concepts. The engineered cartilage with fine structure can bring

关 键 词：关节软骨缺损修复 关节软骨损伤 关节内感染 临床骨科 修复能力 高能量 国内外 

分 类 号：R684[医药卫生—骨科学]