血清腹水白蛋白梯度与肝硬化食管静脉曲张程度的相关性  

Correlation between serumascites albumin gradient and degree of esophageal varices in patients with hepatic cirrhosis

作　　者：张辉[1] 高春[2] 房龙[2] 赵洪川[2] 姚树坤[1] 

机构地区：[1]北京大学中日友好临床医学院消化内科,北京市100029 [2]卫生部中日友好医院消化内科,北京市100029

出　　处：《世界华人消化杂志》2012年第27期2608-2612,共5页World Chinese Journal of Digestology

摘　　要：目的:探讨血清腹水白蛋白梯度(serum-ascites albumin gradient,SAAG)与肝硬化食管静脉曲张程度之间的相关性.方法:收集诊断明确的肝硬化合并腹水患者,根据食管静脉曲张程度分为无或轻度组、中度组和重度组,采用单因素方差分析、相关分析、构建受试者工作特征曲线(receiver operating characteristic,ROC)曲线等方法进行统计学分析.结果:共纳入43例患者,单因素方差分析显示3组之间存在显著差异(F=26.317,P<0.001),Spearman相关系数r=0.759,P<0.001,提示SAAG与食管静脉曲张具有正向相关性.构建ROC曲线得到曲线下面积为0.926,当SAAG取值为20.5g/L时是诊断中重度食管静脉曲张的最佳界值,此时敏感度为87.1%,特异度为83.3%.结论:SAAG与食管静脉曲张具有较好的相关关系,该指标对于中重度食管静脉曲张具有诊断价值.AIM：To explore the correlation between serumascites albumin gradient（SAAG） and the degree of esophageal varices in patients with liver cirrhosis.METHODS：Cirrhotic patients with ascites were collected and divided into three groups according to the degree of esophageal varices：mild group,moderate group and severe group.Oneway ANOVA,correlation analysis and receiver operating characteristic（ROC） curve were used for statistical analysis.RESULTS：A total of 43 cirrhotic patients wereincluded in our study.One-way ANOVA indicated a significant difference in SAAG among the three groups（F = 26.317,P 0.001）.Spearman correlation analysis suggested a positive correlation between SAAG and esophageal varices（r = 0.759,P 0.001）.ROC curve analysis indicated that the area under the ROC curve was 0.926,and the best cut-off value for diagnosis of moderate and severe esophageal varices was 20.5 g/L,with a sensitivity of 87.1% and a specif icity of 83.3%.CONCLUSION：SAAG is correlated well with the degree of esophageal varices in cirrhotic patients,and this parameter has appreciable value in diagnosis of moderate and severe esophageal varices.

关 键 词：血清腹水白蛋白梯度 食管静脉曲张 肝硬化 腹水 相关性 

分 类 号：R575.2[医药卫生—消化系统]