胸苷磷酸化酶在结直肠癌研究中的意义  

Importance of thymidine phosphorylase in colorectal cancer investigation

作　　者：刘剑[1] 高庆[1] 张继民[1] 

机构地区：[1]广州医学院第二附属医院胃肠外科,广东广州510260

出　　处：《中国普通外科杂志》2012年第10期1270-1274,共5页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(81071883/H1612);广东省自然科学基金资助项目(04009573)

摘　　要：研究发现胸苷磷酸化酶具有促进肿瘤血管新生和抗细胞凋亡作用,与肿瘤患者预后转归密切相关。同时,它也是5'-脱氧氟脲苷等5-氟尿嘧啶前体药物的关键转化酶。笔者对胸苷磷酸化酶在结直肠癌组织中的表达、发挥的作用和5'-脱氧氟脲苷在细胞内的激活、治疗等的研究进展进行综述。Investigations reveal thymidine phosphorylase has the effects of promoting tumor angiogenesis and inhibiting cell apoptosis, and is closely related to the prognosis and outcome of the cancer patients. Meanwhile, it is also the key converting enzyme for the prodrugs of 5-fluorouracil such as 5＇-deoxy-5-fluorouridine. This paper reviews the advances in the investigation of thymidine phosphorylase, including its expression and function in colorectal cancer tissue, converting effect on 5＇-deoxy-5-fluorouridine and therapeutic potential.

关 键 词：结直肠肿瘤 胸苷磷酸化酶 新生血管化 病理性 5’-脱氧氟脲苷 

分 类 号：R735.3[医药卫生—肿瘤]