STAT-3和MGMT在人胶质瘤中的表达及意义  

Expression and significance of STAT-3 and MGMT in human gliomas

作　　者：张龙洲[1] 王茂德[1] 

机构地区：[1]西安交通大学医学院附属第一医院神经外科,陕西西安710061

出　　处：《现代肿瘤医学》2012年第10期2039-2041,共3页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:30772226)

摘　　要：目的:探讨STAT3和MGMT在人胶质瘤中的表达及其与肿瘤发生和病理分级之间的关系。方法:用免疫组化法检测并比较80例不同病理级别胶质瘤和15例正常脑组织中STAT3和MGMT的表达情况,并对二者表达做相关性分析。结果:STAT3和MGMT在正常脑组织中均未检测到阳性表达,在瘤组织中的表达均随肿瘤病理级别的升高而增高,相关性分析显示二者的表达存在正相关。结论:STAT3在胶质瘤的发生发展中起重要作用,其高表达可能与参与诱导MGMT的高表达有关。Objective：To explore the expression of STAT-3 and MGMT in human gliomas and its relationship with tumorigenesis and the degrees of malignancy.Methods： Immunohistochemical SP method was employed to study the expression of STAT-3 and MGMT in 80 cases of glioma and 15 cases of normal cerebral tissue used as control group,the relationship of STAT-3 and MGMT expression was analyzed.Results： Both the expression of STAT-3 and MGMT increased as the malignant grade increased,at the same time the expression of STAT3 was positively related to that of MGMT.Conclusion： STAT3 may play a vital role in the progression of glioma through induction of MGMT.

关 键 词：胶质瘤 STAT3 MGMT 

分 类 号：R739.41[医药卫生—肿瘤]