白癜风维医分型与HLA-DQB1等位基因的相关性研究  

Correlation Study between Uygur Classifications of Vitiligo and HLA-DQB1 Alleses

作　　者：热沙来提·依斯坎旦尔[1,2] 库热西·玉努斯[2] 吐尔逊·吾甫尔[3] 伊合帕尔·木拉提[3] 斯拉甫·艾白[1,2] 

机构地区：[1]新疆维吾尔自治区维吾尔医医院重点研究室,新疆医科大学基础医学院生物化学与分子生物学教研室,新疆乌鲁木齐830049 [2]新疆医科大学基础医学院生物化学与分子生物学教研室,新疆乌鲁木齐830011 [3]新疆维吾尔自治区维吾尔医医院皮肤科,新疆乌鲁木齐830049

出　　处：《中国医药指南》2012年第27期1-2,共2页Guide of China Medicine

基　　金：新疆自治区青年科技人才项目(2009zmy14)

摘　　要：目的探讨白癜风维医分型与人类白细胞抗原HLA-DQB1等位基因的相关性及对白癜风易感性的影响。方法收集31名到新疆维吾尔自治区维吾尔医医院的白癜风患者的全血,并抽取其与31例健康对照者全血作为研究标本,提取DNA,用序列特异性引物法进行等位基因检测,对0303和0602两个基因的PCR产物进行统计分析。结果白癜风患者HLA-DQB1*0303的检出率明显高于对照组,HLA-DQB1*0602的阳性率无显著性差异。结论维吾尔族白癜风患者存在较显著的白癜风易感性,HLA-DQB1基因可能与白癜风遗传易感体质相关。Objective To discuss the correlation between syndrome typ of uygur medicine vitiligo and HLA HLA-DQB1 alleles, and their effects on susceptibility of extracting DNA, the aUeles were detected by polymerase chain vitiligo. Methods Whole blood of 31 patients with vilitigo in Xinjiang uygur autonomous region medical hospital of the Uighur vitiligo and 31 healthy people were collected as specimen to reaction （PCR） with sequence specific primer（SSP）, statistical analysis were completed included all related factors. Results Positive rate ofHLA-DQB1 ＊ 0303 was found significantly increased in vilitigo patients than that the control group, HLA-DQB 1 ＊ 0602 had an significant differences. Conclusion The Uighur people with vitiligo exist remarkable susceptibility vitiligo, HLA-DQB 1 genes could and genetic susceptible vitiligo related.

关 键 词：白癜风 易感性 维医分型 HLA-DQB1 等位基因 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]