骨型碱性磷酸酶在乳腺癌术后骨转移中的诊断应用价值  

The diagnostic application value of bone alkaline phosphates in breast cancer postoperative bonemetastases

作　　者：郑广万 

机构地区：[1]江苏省扬州市江都人民医院普外科,225200

出　　处：《中国医师进修杂志》2012年第29期15-17,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的研究骨型碱性磷酸酶（aKP．3）在乳腺癌术后骨转移中的诊断应用价值。方法选取50例乳腺癌术后骨转移患者为研究对象，分析血清AKP-3浓度与骨转移的关系，研究其在乳腺癌术后骨转移显像诊断中的应用。结果50例患者全身骨显像检查分度M09例（18．0％），M114例（28．0％），M220例（40．0％），M37例（14．0％），各构成比比较差异无统计学意义（P〉O．05）。M0、M1、M2、M3，患者血清AKP．3浓度分别为（20．3±6．1）、（42．4±7．4）、（54．1±8．9）、（86．84-9．2）U／L，差异有统计学意义（P〈0．05）。结论AKP．3浓度的检测以及动态观察有助于乳腺癌术后骨转移的早期诊断和预后评判。Objective To study the diagnostic application value of bone alkaline phosphates （AKP-3） in breast cancer postoperative bone metastases. Methods Fifty cases with breast cancer postoperative bone metastases were selected. The relationship between the serum levels of AKP-3 and bone metastases was analyzed, and the diagnostic application value of AKP-3 in breast cancer postoperative bone metastases was studied. Results According to the degree of the bone imaging, among 50 cases,9 cases in the degree M0, the constituent ratio was 18.0%（9/50）; 14 cases in the degree M1, the constituent ratio was 28.0%（ 14/50）; 20 cases in the degree M2, the constituent ratio was 40.0%（20/50）; 7 cases in the degree M3, the constituent ratio was 14.0% （7/50）; the constituent ratios were not statistically significant （P 〉 0.05 ）. The serum levels of AKP-3 in the degree M0, MI, M2, M3 were （20.3 ± 6.1 ）, （42.4 ± 7.4）, （54.1 ± 8.9）, （86.8 ± 9.2） U/L, the differences were statistically significant （P〈 0.05）. Conclusion The detection and dynamic observations of AKP-3 help in the early diagnosis and prognostic evaluation of breast cancer postoperative bone metastases.

关 键 词：乳腺肿瘤 骨转移 骨型碱性磷酸酶 

分 类 号：R737.9[医药卫生—肿瘤]