乳腺浸润性导管癌中Twist的表达与细胞增殖和血管生成的关系  

The expression of Twist in invasive ductal carcinoma of breast and its relationship with cellproliferation and angiogenesis

作　　者：蔡凤林 何春兰 章佳新 周士福[2] 时伟锋[2] 

机构地区：[1]扬州大学临床医学院普通外科,江苏扬州225001 [2]苏州大学附属第四医院肿瘤外科

出　　处：《中国医师进修杂志》2012年第29期17-19,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨Twist在乳腺浸润性导管癌中的表达及其与细胞增殖和血管生成的关系。方法应用免疫组织化学法检测60例乳腺浸润性导管癌组织中Twist和Ki．67的表达情况，计算Ki-67指数和微血管密度（MvD）。结果乳腺浸润性导管癌组织中Twist阳性表达率为56．7％（34／60），Twist阳性患者Ki-67指数、MVD显著高于Twist阴性患者[（57．05±16．37）％比（25．32±16．16）％、（34．30±12．25）％比（23．04±10．45）％，P〈0．05]。结论乳腺浸润性导管癌组织中Twist高表达，Twist可促进肿瘤细胞增殖和肿瘤血管生成，从而成为其促进乳腺癌浸润、转移的途径之一。Objective To study the expression of Twist in invasive ductal carcinoma of breast and its relationship with cell proliferation and angiogenesis. Methods The expression of Twist and Ki-67 was detected in 60 eases with invasive ductal carcinoma of breast by immunohistoehemistry. Ki-67 index and mierovaseular density （MVD） were calculated. Results The positive expression rate of Twist was 56.7% （34/60） in invasive ductal carcinoma of breast. Ki-67 index and MVD in the patients with positive expression of Twist was higher than those in the patients with negative expression of Twist [（57.05 ± 16.37）% vs. （25.32 ± 16.16）%, （34.30 ± 12.25）% vs. （23.04 ± 10.45）%,P〈 0.05]. Conclusions The overexpression of Twist is found in invasive ductal carcinoma of breast. To stimulate cell proliferation and angiogenesis may be one of the pathways of Twist to contribute to the invasion and metastasis of breast cancer.

关 键 词：乳腺肿瘤 TWIST蛋白 KI-67抗原 微血管密度 

分 类 号：R737.9[医药卫生—肿瘤]