97例年轻乳腺癌临床病理特征及预后分析  

The clinicopathological characteristics and prognostic significance of breast cancer in ninety-seven cases of young women

作　　者：张贤雨[1] 张洁[2] 班丽英[2] 

机构地区：[1]河北北方学院附属第一医院,河北张家口075000 [2]大连医科大学附属第一医院肿瘤科

出　　处：《现代预防医学》2012年第19期4968-4972,4976,共6页Modern Preventive Medicine

摘　　要：目的分析97例年轻女性乳腺癌(年龄≤35岁)患者临床病理特征和预后因素。方法 2003年1月～2008年4月某院术后病理确诊的年轻乳腺癌患者97例。观察患者的生存与复发情况,分析其临床病理特征和预后因素。结果至2011年4月,全部患者3y-OS和3y-DFS分别为73.2%(71例)和64.9%(63例)。肿瘤大小为T1、T2、T3+T4患者的3y-OS和3y-DFS分别为92.9%、56.8%、63.6%和83.3%、52.3%、45.5%(P=0.001,P=0.002);腋淋巴结转移为N0、N1、N2+N3患者的3y-OS和3y-DFS分别为87.5%、64.3%、52.4%和79.2%、57.1%、42.9%(P=0.001,P=0.002);临床分期为I期、Ⅱ期、Ⅲ期患者的3y-OS和3y-DFS分别为96.9%、62.5%、60.0%和87.5%、60.0%、44.0%(P=0.001,P=0.001);ER阳性和ER阴性患者的3y-OS和3y-DFS分别为84.2%、57.5%和75.4%、50.0%(P=0.005,P=0.017)。多因素Cox回归分析显示,ER阴性较ER阳性患者的OS(RR=4.534,P=0.000)和DFS(RR=3.754,P=0.000)均差。结论①临床分期、肿瘤大小、腋淋巴结转移情况、ER状态与预后相关;②ER阴性可作为独立的预后危险因素。OBJECTIVE To investigate the clinicopathological characteristics and prognosis in 97 young women with breast cancer（≤35 years old）.METHODS The analysis of clinicopathological features and prognosis was performed in 97 young women with breast cancer who had received synthetic therapy,including surgery,radiotherapy,chemotherapy and endocrine therapy from January 2003 to April 2008.RESULTS Till April 2011,OS and DFS at 3 years were 73.2% and 64.9%,respectively.3y-OS and 3y-DFS in patients with T1,T2,and T3＋T4 were respectively 92.9%,56.8%,63.6% and 83.3%,52.3%,45.5%（P = 0.001,P = 0.002）.3y-OS and 3y-DFS in patients with N0,N1 and N2＋N3 were respectively 87.5%,64.3%,52.4% and 79.2%,57.1%,42.9%（P = 0.001,P = 0.002）.3y-OS and 3y-DFS in patients with stage I,Ⅱ and Ⅲ were respectively 96.9%,62.5%,60.0% and 87.5%,60.0%,44.0%（P = 0.001,P = 0.001）.3y-OS and 3y-DFS in positive and negative ER were 84.2%,57.5% and 75.4%,50.0%（P = 0.005,P = 0.017）.Cox regression analysis showed that negative ER was significantly associated with poorer OS（RR =4.534,P = 0.000） and DFS（RR =3.754,P = 0.000）.CONCULSION Tumor size,axillary lymph nodes metastasis,TNM stage,ER status are associated with 3y-OS and 3y-DFS.Negative ER is a significant independent indicator of prognosis.

关 键 词：乳腺肿瘤 年轻 临床病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]