替吉奥联合顺铂治疗晚期胃癌临床疗效研究  

Curative Effect Analysis of S-1 Combined with Cisplatin in the Treatment of Advanced Gastric Cancer

作　　者：闫泽[1] 兆天欣[1] 邢影[1] 陈丹[1] 何璐璐[1] 

机构地区：[1]辽宁省肿瘤医院内四科,辽宁沈阳110042

出　　处：《现代生物医学进展》2012年第27期5324-5326,共3页Progress in Modern Biomedicine

摘　　要：目的:研究替吉奥联合顺铂治疗晚期胃癌的疗效和安全性。方法:42例晚期胃腺癌患者随机分为观察组(21例)与对照组(21例)两组,观察组采用替吉奥联合顺铂,对照组采用卡培他滨联合顺铂。结果:两组患者疗效间差异无统计学意义(P>0.05)。两组的不良反应主要为骨髓抑制、消化道反应和乏力,观察组Ⅲ～Ⅳ度血小板减少发生率显著低于对照组(P<0.05),Ⅲ～Ⅳ度手足综合征的发生率亦显著低于对照组(P<0.05)。结论:替吉奥联合顺铂治疗晚期胃癌疗效与卡培他滨联合顺铂相当,但其患者耐受性更好,值得临床进一步研究推广使用。Objective： To investigate the safety and efficacy of S-1 combined with cisplatin in the treatment for patients with advanced gastric cancer. Methods： Forty-two patients with advanced gastric cancer were randomly divided into two groups. Patients in observation group （n=21） received S-1 and cisplatin; Patients in control group （n=21） received capecitabine and cisplatin. Results： The efficacy of the two groups showed no statistically significant difference （P〉0.05）. The main untoward effects were myelosuppression, gastroenteric reaction and weakness. Observation group showed,a lower rate of untoward effects than control group. Observation group also showed a lower rate of III-IV thrombocytopenia （P〈0.05） and hand-foot syndrome （P〈0.05） than control group. Conclusions： The treatment of the two groups were evidently effective, with observation group having better tolerance. The regimen could be clinically recommended.

关 键 词：胃肿瘤 替吉奥 卡培他滨 顺铂 治疗结果 

分 类 号：R735.23[医药卫生—肿瘤]