三维适形放疗技术的治疗原发性肝癌的影响因素分析  

Image Factors of the Three-Dimensional Conformal Radiotherapy

作　　者：叶云飞[1] 杨倞[1] 孟岩[1] 孙永健[1] 徐胜[1] 

机构地区：[1]第二军医大学附属东方肝胆外科医院放疗中心,上海200438

出　　处：《现代生物医学进展》2012年第27期5347-5349,5389,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨影响三维适形放疗(3-Dimensional conformal radiotherapy,3DCRT)治疗原发性肝癌的影响因素。方法:收集2008年1月到2010年12月间58例我院原发性肝癌病人,先通过CT扫描定位勾画靶区,经实时验证参数后实施适形放射治疗。观察疗效。并运用Cox回归模型对肿瘤大小、肿瘤分期、肝功能和甲胎蛋白(AFP)水平和照射剂量因素进行分析。结果:完全缓解(CR)13例,部分缓解(PR)35例,总有效(CR+PR)率为82.76%,1、2、3年生存率分别为69.5%、43.10%、27.57%。肿瘤大小、肿瘤分期、甲胎蛋白水平和照射剂量可影响3DCRT效果(P小于0.05),肝功能对3DCRT效果(P小于0.05)。结论:肿瘤分期、肝功能和甲胎蛋白(AFT)水平,分割方式、照射剂量和效应可影响三维适形放疗治疗原发性肝癌的效果。Objective： To investigate the impact of three-dimensional conformal radiotherapy （3-Dimensional conformal radiotherapy with 3DCRT） treatment of primary liver cancer influencing factors. Methods： 58 cases of hospital patients with primary liver cancer in January 2008 to December 2010, the first CT scan positioning outlined target, the implementation of conformal radiation therapy after real-time authentication parameters. Effects were observed. And the use of Cox regression model on the tumor size, tumor stage, liver function and alpha-fetoprotein （AFP） levels and radiation dose factors were analyzed. Results： Complete remission （CR） 13 cases, partial remission （PR）, 35 cases, the total effective （CR＋PR） rate was 82.76%, 1-, 2-and 3-year survival rates were 69.5%, 43.10%, 27.57%. Tumor size, tumor stage, alpha-fetoprotein levels and radiation dose can affect the the 3DCRT effect （P less than 0.05）, liver function, the the 3DCRT effect （P less than 0.05）. Conclusion： Tumor stage, the level of liver function and alpha-fetoprotein （AFT）, partitioned, radiation dose and effects may influence the effect of three-dimensional conformal radiation therapy for primary liver cancer.

关 键 词：三维适形放疗技术 原发性肝癌 影响因素 

分 类 号：R735.7[医药卫生—肿瘤]