CYP 1A1基因Msp1多态性与广西壮族结直肠癌易感性的关系  

Genetic polymorphisms in the cytochrome P450 1A1 Msp1 and susceptibility to colorectal cancer among Zhuang nationality from Guangxi Province

作　　者：黄雪[1] 谭至柔[1] 张瑜红[1] 

机构地区：[1]广西医科大学第一附属医院消化内科,广西南宁530021

出　　处：《中国现代医学杂志》2012年第23期76-79,共4页China Journal of Modern Medicine

摘　　要：目的探讨代谢酶基因CYP 1A1 Msp1多态性与广西地区壮族人群结直肠癌遗传易感性之间的相关性。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测广西地区壮族人群中130例结直肠癌患者和100例健康人的CYP 1A1 Msp1多态性的分布频率,以非条件性Logistic回归模型分别对年龄、性别、吸烟及饮酒状况进行校正后计算优势比(OR)及95%CI。结果 CYP 1A1 Msp1 3种基因型(m1/m1、m1/m2、m2/m2)分布频率在结直肠癌组分别为42.1%、43.7%和14.2%,在正常对照组分别为40.8%、45.7%和13.5%,两组间的频率分布在性别、年龄、吸烟、饮酒状况调整后差异无统计学意义(P>0.05)。携带CYP 1A1Msp1突变m2基因型的个体较携带m1/m1基因型的个体患结直肠癌的风险增加(OR=1.10),但差异无统计学意义(P=0.63)。按照吸烟因素分层后,这种差异仍无统计学意义(P>0.05)。结论单一基因CYP 1A1 Msp1位点多态性与广西地区壮族人群结直肠癌易感性无相关性。【Objective】 To evaluate the association between genetic polymorphisms of cytochrome P450 1A1 and susceptibility to colorectal cancer among Zhuang nationality from Guangxi Province of China.【Methods】 A total of 130 cases of primary colorectal cancer and 100 controls of Zhuang nationality from Guangxi Province were included in this study.Genotypes of CYP 1A1 Msp1 genes were determined by polymerase chain reaction-restriction fragment length polymorphism.The Association between these genotypes and risk of colorectal cancer were evaluated using logistic regression analysis to calculate odds ratios（OR） and 95% confidence intervals（CI） after adjustment for age,sex,smoking status and drinking status.【Results】 The frequencies of CYP 1A1 m1/m1,m1/m2,m2/m2 gene types were 42.1%,43.7%,14.2% amongst the colorectal cancer and were 40.8%,45.7%,13.5% amongst the controls respectively.Statistically no differences were found between patients with colorectal cancer and control groups for the CYP 1A1 Msp1 genotypes.After adjustment for age,sex,smoking status and drinking status（P 0.05）,the individuals who carried with CYP 1A1 m2 allele genotype had an increased risk of colorectal cancer compared to those carrying CYP 1A1 m1/m1 genotype（OR=1.10）,but no remarkable relationship was observed between the difference（P 0.05） after data was further adjusted by smoking status.【Conclusion】 There was no association between the polymorphisms of CYP 1A1 MspI and colorectal cancer in Zhuang nationality from Guangxi Province of China.

关 键 词：结直肠癌 基因多态 代谢酶基因 CYP1A1 

分 类 号：R574.6[医药卫生—消化系统]