鼻咽癌患者染色体畸变率与血清EBVCA-IgA抗体水平关系的研究  

A Study of the Relation between Chromosomal Aberration Rate and EBVCA-lgA Antibody Level in Patients with Nasopharyngeal Carcinoma

作　　者：杨新明[1] 游孟高 李舜农[1] 蒋绪成 蒋新伟[1] 

机构地区：[1]湖南医科大学附属第二医院耳鼻咽喉科

出　　处：《中国肿瘤临床》1990年第4期208-210,共3页Chinese Journal of Clinical Oncology

摘　　要：本研究采用特殊的细胞培养方法,观察32例鼻咽癌患者和22例健康对照外周血细胞染色体结构畸变;并同时测定血清EBVCA—IgA抗体。结果发现:1.鼻咽癌组染色体结构畸变率明显高于健康对照组,2.EBVCA—IgA抗体阳性患者染色体畸变率明显高于阴性组患者;3.染色体畸变率随EBVCA—IgA抗体滴度的升高而有增高趋势。文中简要讨论了EB病毒与遗传因素在鼻咽癌发生、发展中的可能作用。The cultured peripheral lymphocyte chromosomal aberration and EBVCA-IgA antibody in the serum of 32 patients with nasopharyngeal cancer and 22 healthy controis were studied. The results showed that: 1. Chromosome structural aberration rate in patients (10.69％) was significantly higher than that of the control group (0.95％) (P<0.001). 2. The patients with positive EBVCA-IgA antibody demonstrated significantly higher chromosomal aberration rate as compared with those with negative EBVCA-IgA antibody (P<0.001), 3. Chromosomal aberration rate was elevated with increasing EBVCA-IgA antibody titer.

关 键 词：鼻咽肿瘤 染色体畸变率 EBVCA-IgA抗体 

分 类 号：R739.630.4[医药卫生—肿瘤]