兴奋毒损伤尾核致认知障碍的动物模型  

An Animal Model for Cognitive Deficit Following Excitotoxic Lesion of the Caudate Nucleus

作　　者：李从德[1] 耿志国[1] 谯敏[1] 张世仪 

机构地区：[1]湖北三峡学院医学院医学基础部,湖北宜昌443003

出　　处：《湖北三峡学院学报》2000年第2期73-76,共4页Journal of China Three Gorges University(Humanities & Social Sciences)

摘　　要：用微量兴奋毒———海人酸损伤大鼠尾核后 ,自发活动及一般状况不受影响 ,其被动回避反应的短时和长时记忆下降 ,主动回避反应的学习能力差 ,空间转换作业能力也下降Kainic acid(0 3μg)was microinjected into bilateral anteriomediac caudate mueleas in rats respectively Ten days after operatation, animals behavior was tested For passive avoidance response, retention of short term and long term memory was markedly impaired in KA group In addition,we found that learning capacities in active avoidance response and spatial alternation task were also impaired, the rats kept normal health and motor ability

关 键 词：海人酸 尾核 认知障碍 动物模型 兴奋毒 损伤 

分 类 号：R749.160.2[医药卫生—神经病学与精神病学]