ADH1B与ALDH-2基因多态性与中国人群食管癌发病风险的Meta分析  

Genetic polymorphisms of ADH1B and ALDH-2 associated with risk of esophageal cancer:a meta-analysis

作　　者：段富交[1] 宋春花[1] 崔姝沥[2] 王龙智[1] 甄茜[1] 曲红红[1] 王鹏[1] 王凯娟[1] 张建营[1] 代丽萍[1] 

机构地区：[1]郑州大学公共卫生学院,郑州450001 [2]河南工业大学国际学院生物学系

出　　处：《卫生研究》2012年第5期723-729,共7页Journal of Hygiene Research

基　　金：国家自然科学基金项目(No.30872181;81072360);河南省高校科技创新人才支持计划(No.2010HASTIT027);河南医学科技攻关项目(No.200903009)

摘　　要：目的探讨中国人乙醇脱氢酶1B(ADH1B)和乙醛脱氢酶-2(ALDH-2)的基因多态性与食管癌发病风险的关系。方法检索中外文数据库,获得有关ADH1B和ALDH-2位点的多态性与食管癌发病风险的病例-对照研究资料,对各位点以及与饮酒的交互作用进行Meta分析,得到合并的OR值及其95%CI。结果等位基因ADH1B*1和ALDH-2*2可增加食管癌的发病风险。基因型ADH1B*1/*2和ADH1B*1/*1的OR值分别为1.24(95%CI 1.10-1.41)和3.05(95%CI 1.94-4.77);基因型ALDH-2*1/*2和ALDH-2*2/*2的OR值分别为1.6(95%CI 1.01-2.03)和0.77(95%CI 0.28-2.09)。在饮酒人群中,与基因型ADH1B*2/*2相比,ADH1B*1/*2+*2/*2的OR=3.13(95%CI 2.17-4.51);与基因型ALDH-2*1/*1相比,ALDH-2*1/*2+*2/*2的OR=4.12(95%CI 1.98-8.56)。结论在中国人群中,等位基因ADH1B*1和ALDH-2*2均能增加食管癌患病的风险,且饮酒可以增加这一风险。Abstract： Objective To investigate the association of genetic polymorphisms of alcohol dehydrogenase-1B （ADH1B） and aldehyde dehydrogenase-2 （ALDH-2） with risk of esophageal cancer （EC） in China. Methods A comprehensive search of the database was performed to identify all case-control studies of ADH1B and ALDH-2 polymorphisms associated with esophageal cancer and their interactions with alcohol drinking. Meta- analysis was carried out for calculation of pooled OR value and its corresponding 95% CI. Results The ADH1B ＊ 1 and ALDH-2 ＊ 2 allele were found to be associated to increased risk of EC, with odds ratios （OR） being 1.24 （95% CI 1. 10 - 1.41） and 3.05（95% CI1.94-4.77） for the ADH1B＊ 1/.2 and ADH1B＊ 1/＊ 1, and 1.6（95%CI 1.01 - 2.03） andO. 77（95% CI 0. 28 -2.09） for the ALDH-2＊ 1/,2 and ALDH-2＊2/＊2 respectively. When compared with the ADH1B ＊ 2/＊ 2 genotype in drinkers, the ADH1B ＊ 1/ ＊ 2 ＋ ＊ 2/＊ 2 can increase risk of EC （OR =3.13, 95% CI2. 17 -4.51）. ALDH-2 ＊ 1/＊ 2 ＋ ＊ 2/＊ 2 showed an increased risk to EC among drinks compared with the ALDH-2 ＊ 1/＊ 1 genotype （OR = 4. 12, 95% CI1.98 -8.56）. Conclusion ADH1B ＊ 1 and ALDH-2 ＊ 2 allele can increase the risk of EC in china, which can be modified by alcohol consumption.

关 键 词：食管癌 META分析 乙醇脱氢酶1B 乙醛脱氢酶-2 

分 类 号：R735.1[医药卫生—肿瘤] Q78[医药卫生—临床医学]