高强度聚焦超声壳式辐照的不同线间隔时间对离体牛肝组织的影响  

Impacts of high intensity focused ultrasound peripheral scanning with different doublet interval time on irradiation of in vitro ox-liver tissue

作　　者：银丽[1] 邹建中[1] 伍烽[1] 卜锐[1] 焦娇[1] 赵欣[1] 

机构地区：[1]重庆医科大学生物医学工程学院省部共建超声医学工程国家重点实验室超声医学工程重庆市市级重点实验室,重庆400016

出　　处：《中国介入影像与治疗学》2012年第10期748-751,共4页Chinese Journal of Interventional Imaging and Therapy

基　　金：国家自然科学基金重大仪器专项(81127901)

摘　　要：目的探讨不同线间隔时间对高强度聚焦超声(HIFU)壳式辐照离体牛肝组织的影响。方法根据线间隔时间将60个牛肝随机分为6组:2min组、4min组、6min组、8min组、10min组、12min组,每组用相同辐照剂量进行HI-FU壳式辐照同样大小的ROI的周边,对ROI内部区域不进行辐照。结果每组辐照区均形成完整封闭的凝固性坏死带。各组凝固性坏死体积依次缩小,能效因子依次增大,辐照效率依次降低。除2min组和4min组外,其余各组未见明显ROI外周组织损伤。结论随着线间隔时间缩短,坏死体积增大,能效因子减小,辐照效率增高;6min是HIFU壳式辐照离体牛肝组织的最佳线间隔时间。Objective To investigate the impacts of high intensity focused ultrasound （HIFU） peripheral scanning with different doublet interval time on irradiation of in vitro ox-liver tissue. Methods Totally 60 pieces of ox-liver tissues were randomly divided into 6 groups （2, 4, 6, 8, 10, 12 min） according to doublet interval time. Each group was irradiated on the periphery of same ROI with same dose using HIFU. Results Each group had formed integrated confinement of lesion. The tissue outside of ROI of 2 rain group and 4 rain group presented coagulation necrosis, when the other groups did not. Among 6 groups, the volume of the lesion decreased, while energy efficiency factor （EEF） increased and the efficiency of irradiation decreased in sequence. Conclusion With the doublet interval time decreases, the volume of the lesion increases, while EEF decreased and the efficiency of irradiation increases. The best doublet interval time of HIFU peripheral scanning on irradiation of in vitro ox-liver tissue is 6 min.

关 键 词：高强度聚焦超声消融术 壳式辐照 线间隔时间 

分 类 号：R73-3[医药卫生—肿瘤]