卵巢癌综合治疗后^(18)F-FDG PET/CT随访的临床价值  

Value of ^(18)F-FDG PET/CT in Follow-up of Ovarian Cancer Patients after Therapy

作　　者：童林军[1] 陈虞梅[1] 施一平[1] 万良荣[1] 陈涛[1] 

机构地区：[1]上海交通大学医学院附属仁济医院PET/CT中心

出　　处：《中国医学计算机成像杂志》2012年第5期439-442,共4页Chinese Computed Medical Imaging

摘　　要：目的:探讨^(18)F-FDG PET/CT显像在卵巢癌综合治疗后随访的应用价值及对临床治疗决策的影响。方法:回顾性分析在本中心接受PET/CT显像的152例卵巢癌治疗后患者,收集及分析临床资料、CA125及常规影像学结果。将患者按不同的PET/CT检查指征分为5组,与临床随访结果进行对比,分析PET/CT在卵巢癌治疗随访的应用价值及对临床治疗决策的影响。结果:137例有随访结果者纳入本研究,其中105例复发、32例无复发。PET/CT诊断卵巢癌复发的总体敏感度、特异度、准确率、阳性预测值、阴性预测值分别为:98.3%、91.2%、96.8%、97.5%、93.9%。PET/CT可为临床疑有复发、病情评估及疗效评价患者制定准确的治疗决策。结论:PET/CT检查对卵巢癌复发有着极高的诊断效率,可为临床提供最优化的治疗方案。Purpose： To evaluate the use of ^18F-PET/CT in follow-up of ovarian cancer patients after therapy. Methods： A retrospective study was performed on 152 ovarian cancer patients after therapy. The following information was collected and analyzed： clinical material, CA125 and traditional imaging result. According to the indication for PET/CT, the patients were divided into 5 groups. The role of ^18F-PET/CT in evaluation of surveillance and clinical management of ovarian cancer patients after therapy compared with the result of clinical follow-up was analyzed. Results： Of 137 patients with follow-up results, 105 patients were diagnosed as recurrence and 32 as disease free after long duration follow-up. The diagnostic sensitivity, specificity, accuracy, positive predictive value, negative predictive value were 98.3%, 91.2%, 96.8%, 97.5%, 93.9%, respectively. PET/CT was especially useful for the correct clinical therapeutic decision making for the patients whose PET/CT indications were to diagnose suspected recurrence, for the assessment of disease extent and for the evaluation of therapeutic response. Conclusion： PET/CT has extremely high diagnostic value for recurrent ovarian cancer and is specifically helpful in optimizing the selection of patients for appropriate treatment.

关 键 词：卵巢癌 复发 氟化去氧葡萄糖 体层摄影术 发射型计算机 诊断 

分 类 号：R737.31[医药卫生—肿瘤]