慢性淋巴细胞白血病的临床免疫分型和细胞周期分析  

Clinical, immunophenotypic and cell cyclic analysis of chronic lymphocytic leukemia(CLL)

作　　者：汪月增[1] 季红[1] 阎影[1] 刘海川[1] 刘成贵[2] 李岩[2] 

机构地区：[1]中国人民解放军军医进修学院血液内科 [2]中国人民解放军军医进修学院单克隆室

出　　处：《军医进修学院学报》1990年第2期107-110,共4页Academic Journal of Pla Postgraduate Medical School

摘　　要：15例慢性淋巴细胞白血病(CLL)用一组单克隆抗体作免疫分型。13例为B-CLL,主要表型为CD20^+、HLA-Dr^+、SmIg^+、CD5/Em^+。2例T-CLL,1例Ts-CLL,1例为Dr^+的T-CLL。CLL骨髓中Go+G_1期细胞为91.1±2.3％(对照76.0±5.1％),S+G2M期细胞为8.9±2.3％(对照23.9±5.1％),外周血中各种周期的细胞比例与骨髓无显著差别。3例CLL在病程中发生幼淋样变。对CLL的临床过程,细胞化学,和免疫学改变作了分析。15 cases of CLL were immunophenotyped with a panel of monoclonal antibodies. 13 cases BCLL, which was characterized by CD_20^+, HLA-Dr^+, Smlg^+, CDs^+and Em^+. 2 cases were T-CLL, one with Ts phenotype and the other with Dr^+T-CLL. The ratio of G0+G1 cells in bone marrow of CLL was 91.1±2.3%(76.0±5.1% in controls), while S+G_2M cells was 8.9±2.3% (23.9± 5.1%in controls). The ratios of various cyclic cells were similar in bone marrow and in peripheral blood. Prolymphocytoid transformation developed in late stage of 3 CLL patients. The clinical course, cytochemistry and immunologic changes in CLL are also analysed in this paper.

关 键 词：单克隆抗体 免疫学技术 细胞周期 白血病 

分 类 号：R733.72[医药卫生—肿瘤]