非典型抗精神病药对首发精神分裂症患者生活质量和家庭功能的影响  

The effect of atypical antipsychotics for the quality of life and family function in first episode schizophrenic patients

作　　者：孔霞[1] 翟金国[2] 陈敏[2] 苏中华[3] 张传芝[3] 

机构地区：[1]济宁医学院附属济宁市第一人民医院,山东省272013 [2]济宁医学院精神卫生学院 [3]济宁医学院附属第二医院

出　　处：《中华脑科疾病与康复杂志（电子版）》2012年第1期6-11,共6页Chinese Journal of Brain Diseases and Rehabilitation（Electronic Edition）

摘　　要：目的比较4种非典型抗精神病药对首发精神分裂症患者生活质量和家庭功能的影响。方法将济宁医学院第二附属医院确诊的176例首发精神分裂症患者随机分为利培酮组（44例，予以利培酮2～6mg／d，分1～2次口服）、喹硫平组（43例，予以喹硫平200—600mg／d，分2次口服）、奥氮平组（45例，予以奥氮平10—30mg／d，分1～2次口服）和阿立哌唑组（44例，予以阿立哌唑10～30mg／d，分1～2次口服），治疗半年，比较治疗前后精神症状、生活质量和家庭功能的变化。同时，将176例患者患病前、患病后及治疗后的家庭功能障碍比例进行比较。采用SPSS16．0进行统计学分析。结果（1）阳性和阴性症状评定量表（PANSS）、健康状况问卷（sF一36）各因子分四组治疗前后比较，经配对t检验，差异均有统计学意义（P均〈0．05）；治疗后组间两两比较，SF-36精力因子奥氮平组得分显著低于其他各组，社会功能因子利培酮组得分显著高于其他各组（P均〈0．05）。（2）患病前存在功能障碍的家庭比例与对照组比较差异有统计学意义（x^2=4．236，P〈0．05）。患病后出现功能障碍的家庭与对照组比较差异有统计学意义（x^2=68．125，P〈0．01）。治疗后与治疗前比较，经配对矿检验差异有统计学意义（x^2=12．274，P〈0．01）。（3）APGAR总分及情感度治疗后组间比较差异有统计学意义（F^PGAR=3．436，P〈0．05，F情感=3．662，P〈0．05），组间两两比较家庭关怀指数（APGAR）总分奥氮平组和阿立哌唑组均优于利培酮组和喹硫平组；情感度喹硫平组和奥氮平组均优于利培酮组和阿立哌唑组。结论利培酮、喹硫平、奥氮平和阿立哌唑均能显著改善精神分裂症患者的精神症状、生活质量和家庭功能；利培酮对社会功能的改善较好，奥氮平对精力的改善较差；奥氮平和阿立哌唑对家�Objective To compare the effect of risperidone, quetiapine, olanzapine and aripiprazole on the quality of life and family function in first episode schizophrenic patients. Methods One hundred and seventy-six schizophrenic patients were divided into four groups and treated for six months, the four groups were group risperidone（n =44, patients took risperidone 1 to 2 times orally, 2 to 6 mg each time a day）, group quetiapine（ n = 43, patients took quetiapine 2 times orally, 200 to 600 mg each time a day）, group olanzapine （n =45, patients took olanzapinel to 2 times orally, 10 to 30 mg each time a day） and group aripiprazole （ n = 44, patients took aripiprazole 1 to 2 times orally, 10 to 30 mg each time a day） respectively. All patients were assessed with positive and negative syndrome scale（PANSS） , short form 36 health survey questionnaire（SF-36） and family APGAR index（APGAR）. Results （1）There were significant differences in the scores of PANSS and all factors of SF-36 between prenmrbid and postmorbid （ paired-t test, all P 〉 0. 05）. After treatment, the scores of the factor of SF-36 energy of olanzapine group were lower than those of other groups, and the scores of the factor of SF-36 social function of risperidone group were higher than those of other groups （ all P 〈 0.05 ）. （2） No matter premorbid and postmorbid phase in schizophrenia group, was the dysfuncition family proportion higher than that of control group（x2 = 4. 236, P 〈 0.05, X2 = 68. 125, P 〈 0.01 ）. There were significant differences in the dysfuncition family proportion between before and after treatment in schizophrenia group （X2 = 12. 274, P 〈 0.01 ）. （3） After treatment , there were significant differences on the scores of APGAR and affection among the four groups（FApGA. =3. 436, P 〈0.05, Fosfectio,, -= 3. 662, P 〈 0.05 ）. The scores of APGAR of olanzapine group and aripiprazole group were more higher than that of risperidone group and quetiapine group. The scores of af

关 键 词：精神分裂症 抗精神病药 非典型 生活质量 家庭功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]